Efek Pemberian Maserasi Taoge (Vigna radiata) terhadap Profil Hematologi dan Biokimia Darah Tikus Betina
andriyanto Andriyanto(1*), Leliana Nugrahaning Widi(2), Rindy Fazni Nengsih(3), Hamdika Yendri Putra(4), Mawar Subangkit(5), Elpita Tarigan(6), Yusa Irarang(7), Aulia Andri Mustika(8), Lina Noviyanti Sutardi(9), Wasmen Manalu(10)
(1) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(2) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(3) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(4) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(5) Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(6) Fakultas Kedokteran Hewan Institut Pertanian Bogor
(7) Fakultas Kedokteran Hewan Institut Pertanian Bogor
(8) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(9) Departemen Klinik, Reproduksi dan Patologi Fakultas Kedokteran Hewan Universitas Gadjah Mada
(10) Departemen Anatomi, Fisiologi dan Farmakologi Fakultas Kedokteran Hewan Institut Pertanian Bogor
(*) Corresponding Author
Abstract
Taoge memiliki berbagai manfaat farmakologis yang berpotensi besar untuk meningkatkan kesehatan. Penelitian ini dilakukan untuk mengeksplorasi keamanan dari konsumsi maserasi taoge melalui pengamatan terhadap profil hematologi dan biokimia darah. Sebanyak 15 ekor tikus betina galur Sprague Dawley berumur 8 minggu, memiliki bobot badan 220-230 g, dan belum pernah bunting dikelompokkan secara acak ke dalam 3 kelompok perlakuan (n=5 tikus), yaitu kelompok kontrol (diberi air mineral); kelompok maserasi taoge 1%; dan kelompok maserasi taoge 5%. Pemberian maserasi dilakukan melalui air minum dan dilaksanakan selama 20 hari. Hasil menunjukkan bahwa secara umum perlakuan maserasi taoge tidak memberikan pengaruh nyata (P>0.05) terhadap profil hematologi dan biokimia darah tikus percobaan. Terdapat peningkatan signifikan (P>0.05) pada kadar hemoglobin pada kelompok maserasi taoge 1% dibandingkan dengan kontrol yang lebih tinggi dari nilai normal. Hal yang serupa juga terjadi pada nilai neutrofil yang lebih tinggi dari nilai normal namun tidak berbeda nyata dengan kontrol (p>0.05). Selain keduanya, semua parameter menunjukkan nilai yang tidak berbeda nyata dibandingkan dengan kelompok kontrol dan berada pada rentang nilai normal.. Hal ini mengindikasikan bahwa pemberian maserasi tauge tidak memberikan efek negatif dan toksik pada dosis 1 dan 5% terhadap profil darah serta fungsi organ hati dan ginjal.
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DOI: https://doi.org/10.22146/jsv.73351
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