Cost Effectiveness Analysis of Crystalloid and Crystaloid-Colloid Combination on Dengue Fever without Shok in Bhakti Asih General Hospital Tangerang

https://doi.org/10.22146/jmpf.33367

Suratni Suratni(1*), Yusi Anggriani(2), Agusdini Banun(3)

(1) a) Magister Kefarmasian, Pancasila University, Jakarta b) Bhakti Asih General Hospital, Tangerang, Banten
(2) Magister Kefarmasian, Pancasila University, Jakarta
(3) Bhakti Asih General Hospital, Tangerang, Banten
(*) Corresponding Author

Abstract


Dengue fever is an infectious disease caused by virus transmitted through Aedes aegypty. The high incidence dengue fever can lead to increased healthcare costs. This study was conducted to analyze the effectiveness and direct cost of medical patients dengue fever without shock use fluid therapy by comparing crystalloid and crystalloid colloid combination. The subjects were 171 patients divided into two groups: 106 patients with crystalloid and 65 patients with crystalloid colloid combination. Assessed of effectiveness treatment and the mean medical costs. The results showed reviewed from hematocrit value no difference (p>0.05) in both study groups. The mean total cost of treatment for crystalloid Rp 4.005.223, the crystalloid colloid combination Rp 5.525.407. The highest cost of drug costs was 31.75% of the total cost crystalloid, 40.9% of the total cost crystalloid colloid combination. There was a significant difference between mean cost and two study groups (p0.05) with effectiveness treatment. Conclusion crystalloid have the same effectiveness as crystalloid colloid combination fluids at lower costs.

Keywords


cost effectiveness analysis; crystalloid solution; crystalloid-colloid combination; dengue fever; hematocrite

Full Text:

PDF


References

1. Kementerian Kesehatan RI. Demam Berdarah Dengue. Bul Jendela Epidemiol. 2010;2:48.

2. Suaya JA, Sah BK, Siqueira JB, et al. Economic Cost of Officially Reported Dengue Cases in Eight Countries in the Americas and Asia. Am J Trop Med Hyg. 2008;79(6):34. doi:10.4269/ajtmh.2009.80.846

3. Cheah WK, Ng KS, Marzilawati AR, Lum LCS. A review of dengue research in Malaysia. Med J Malaysia. 2014. http://www.mendeley.com/research/review-dengue-research-malaysia.

4. World Health Organization and Special Programme for Research and Training in Tropical Diseases. Handbook for clinical management of dengue. http://www.wpro.who.int/mvp/documents/handbook_for_clinical_management_of_dengue.pdf. Published 2012.

5. Cohen L, Manion L, Morrison K, et al. National guidelines for Clinical management of Dengue Fever, Dec 2014. BMC Public Health. 2013;13(10):60-66. doi:10.1017/CBO9781107415324.004

6. Chen Khie, Pohan HT, Sinto R. Diagnosis dan terapi cairan pada demam berdarah dengue. Medicinus. 2009; 22(1): p.5-10.

7. Annane D, Siami S, Jaber S, et al. Effects of fluid resuscitation with colloids vs crystalloids on mortality in critically ill patients presenting with hypovolemic shock - The CRISTAL randomized trial. JAMA - J Am Med Assoc. 2013;310(17):1809-1817. doi:10.1001/jama.2013.280502

8. Upadhyay M, Singhi S, Murlidharan J, Kaur N, Majumdar S. Randomized evaluation of fluid resuscitation with crystalloid (saline) and colloid (polymer from degraded gelatin in saline) in pediatric septic shock. Indian Pediatr. 2005;42:223-231. doi:10.1056/NEJMoa1500896

9. Permenkes no. 59. Permenkes RI No. 59 tahun 2014 Tentang Standar Tarif Pelayanan Kesehatan dalam Penyelenggaraan Program Jaminan Kesehatan. Dep Kesehat RI. 2014:7-8.

10. Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia No. 28 Tahun 2014 Tentang Pedoman Pelaksanaan Program Jaminan Kesehatan Nasional. Jakarta: Kementerian Kesehatan;2014.

11. Kemendagri. Undang-Undang Republik Indonesia Nomor 44 Tahun 2009 Tentang Rumah Sakit. J Chem Inf Model. 2013;53(9):1689-1699. doi:10.1017/CBO9781107415324.004

12. Pedoman penerapan kajian farmakoekonomi. Jakarta: Dirjen Binfar dan Alkes Kementrian Kesehatan Republik Indonesia; 2013: p. 5,11,22,27,38.

13. Buxton MJ, Drummond MF, Van Hout BA, et al. Modelling in economic evaluation: An unavoidable fact of life. Health Econ. 1997;6(3):217-227. doi:10.1002/(SICI)1099-1050(199705)6:33.0.CO;2-W

14. Rascati L Karen. Essentials of pharmacoeconomics. Philadelphia: Lippincottt William & Wilkins a Wolters Kluwer business; 2009.p.1-66.

15. Afdal AF. Farmaekonomi pisau analisis Terbaru Dunia Farmasi. Jakarta: Samitra Media Utama ; 2011.p.5.

16. Rumah Sakit Umum Bhakti Asih. Laporan kinerja tahun 2014 dan 2015 bidang pelayanan RSU Bhakti Asih. Tangerang Indonesia ; 2016.

17. Pramita P Adinda. Pengaruh status gizi terhadap demam berdarah dengue di Instalasi rawat inap anak RSUD Tangerang [Tesis]. Universitas Islam Negeri Jakarta; 2012.

18. Candra A. Demam Berdarah Dengue : Epidemiologi , Patogenesis , dan Faktor Risiko Penularan Dengue Hemorrhagic Fever : Epidemiology , Pathogenesis , and Its Transmission Risk Factors. Demam Berdarah Dengue Epidemiol Patog dan Fakt Risiko Penularan. 2010;2(2):110-119.

19. Raya Agustinawati. Peranan sanitasi lingkungan dan status gizi pada kehanan terhadap kejadian penyakit DBD (studi pada balita Di Kabupaten Lampung Selatan) [Tesis]. Universitas lampung; 2016.

20. Perel P, Roberts I, Ker K, Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients ( Review ) Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Collab. 2013;(3):1-71. doi:10.1002/14651858.CD000567.pub6.Copyright

21. Nadra M. Analisis efektivitas biaya penggunaan albumin Me too dibandingkan dengan albumin inovator pada pasien kanker payudara stadium lanjut di Rumah Sakit Kanker Dharmais [Tesis]. Universitas Indonesia. Jakarta; 2013.

22. World Health Organization. Dengue: guidelines for diagnosis, treatment, prevention, and control. Spec Program Res Train Trop Dis. 2009:x, 147. doi:WHO/HTM/NTD/DEN/2009.

23. Singh A, Ali S. Polygeline in hypovolemia due to traumatic injury: Results of an open label study in Indian population. Int J Crit Illn Inj Sci. 2016;6(1):21-24. doi:10.4103/2229-5151.177362

24. Lum LCS, Suaya JA, Tan LH, Sah BK, Shepard DS. Quality of life of dengue patients. Am J Trop Med Hyg. 2008;78(6):862-867. doi:78/6/862 [pii]

25. Marón GM, Clará AW, Diddle JW, et al. Association between nutritional status and severity of dengue infection in children in el salvador. Am J Trop Med Hyg. 2010;82(2):324-329. doi:10.4269/ajtmh.2010.09-0365

26. Trang NTH, Long NP, Hue TTM, et al. Association between nutritional status and dengue infection: A systematic review and meta-analysis. BMC Infect Dis. 2016;16(1). doi:10.1186/s12879-016-1498-y



DOI: https://doi.org/10.22146/jmpf.33367

Article Metrics

Abstract views : 7700 | views : 8413

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats