Korelasi indeks massa tubuh terhadap rasio trigliserida dan high-density lipoprotein-cholesterol pada wanita usia subur dengan obesitas

https://doi.org/10.22146/ijcn.69245

Nina Indriyani Nasruddin(1*), Juminten Saimin(2), Ramadhan Tosepu(3)

(1) Program Studi Magister Kesehatan Masyarakat, Pasca Sarjana Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
(2) Bagian Obsgyn, Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
(3) Bagian Ilmu Kesehatan Masyarakat, Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
(*) Corresponding Author

Abstract


Body mass index correlation with triglyceride and high-density lipoprotein-cholesterol ratio of reproductive age women with obesity

Background: Obesity in women of reproductive age is thought to be one of the triggers of coronary heart disease. Body mass index (BMI) correlates well with the percentage of body fat, which is a strong indicator of coronary heart disease. Accumulation of visceral adipocytes releases excess free fatty acids, resulting in increased triglyceride synthesis. Furthermore, in a state of hypertriglyceridemia, there is a decrease in HDL levels and an increase in HDL catabolism resulting in decreased HDL levels. Examination of the ratio of triglyceride levels and high-density lipoprotein cholesterol (TG/HDL-C) is a strong indicator of cardiovascular disease.

Objective: The aim of his study was to investigate the correlation between BMI and TG/HDL-C ratio in women of reproductive age.

Methods: Using an analytical approach with a cross-sectional design. Furthermore, height and weight were measured with Smic ZT 120. At the same time as this examination, venous blood was taken from the median cubital area to be used to check the level of triglycerides and HDL-C in the serum. TG examination with GPO-PAP and HDL-C direct method. The bivariate analysis uses the Spearman Rank correlation test, while the multivariate analysis uses the linear regression test.

Results: TG levels were 106 (34-363) mg/dl, HDL-C levels were 48.19 ± 9.91 mg/dl, and the ratio between the two was 2.26 (0.52-9.58). Spearman Rank analysis obtained the value of r was 0.573, p-value 0.0001.

Conclusions:  There is a significant positive correlation between BMI and the ratio of TG/HDL-C levels in adult women of reproductive age with obesity.


Keywords


body mass index; obesity; TG/HDL-C ratio; women of reproductive age

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References

  1. WHO. Prevalence of overweight among adults, BMI >= 25 (age-standardized estimate) (%). [series online] 2020 [cited 2020 Dec 18]. Available from: URL: https://www.who.int/data/gho/data/indicators/indicator-details/GHO/prevalence-of-obesity-among-adults-bmi-=-30-(age-standardized-estimate)-(-)
  2. Ritchie H, Roser M. Obesity. Our world data. [series online] 2017 [cited 2020 Aug 6]. Available from: URL: https://ourworldindata.org/obesity
  3. Kementerian Kesehatan RI. Riset kesehatan dasar (Riskesdas) tahun 2018. Jakarta: Kementerian Kesehatan Republik Indonesia; 2018.
  4. Dinas Kesehatan Provinsi Sulawesi Tenggara. Profil Kesehatan Provinsi Sulawesi Tenggara. Sulawesi Tenggara: Dinas Kesehatan Provinsi Sulawesi Tenggara; 2017.
  5. World Bank. The double burden of malnutrition in Indonesia. [series online] 2013 [cited 2020 Dec 18]. Available from: URL: https://openknowledge.worldbank.org/handle/10986/17007
  6. Achadi EL, Kusharisupeni K, Atmarita A, Untoro R. Status gizi ibu hamil dan penyakit tidak menular pada dewasa. Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal). 2012;7(4):147. doi: 10.21109/kesmas.v7i4.47
  7. Khusna FH, Murbawani EA. Hubungan indeks massa tubuh dengan rasio trigliserida/high-density lipoprotein (TG/HDL) pada remaja. J Nutr Coll. 2016;5(2):85–91.
  8. Centers for Disease Control and Prevention (CDC). Assessing your weight. [series online] 2020 [cited 2021 Sep 5]. Available from: URL: https://www.cdc.gov/healthyweight/assessing/index.html
  9. WF Ganong. Ganong’s medical physiology. 24th ed. Jakarta: EGC; 2012.
  10. Managerxot J, Soleha M. Kadar kolesterol tinggi dan faktor-faktor yang berpengaruh terhadap kadar kolesterol darah. J Biotek Medisiana Indones. 2012;1(2):85–92.
  11. Borrayo G, Basurto L, González-Escudero E, Diaz A, Vázquez A, Avelar F, et al. TG/HDL-C ratio as cardio-metabolic biomarker even in normal weight women. Acta Endocrinol (Buchar). 2018;14(2):261–7. doi: 10.4183/aeb.2018.261
  12. Mallick AK, Ahsan M, Das B, Rai S. A correlation study of lipid profile with body mass index and waist hip ratio in Rohilkhand region. Int J Med Res Rev. 2018;6(3):186–91. doi: 10.17511/ijmrr.2018.i03.09
  13. Kementerian Kesehatan RI. PMK no 41 tentang pedoman gizi seimbang. Jakarta: Kemenkes RI; 2014.
  14. IPAQ. Guidelines for data processing and analysis of the international physical activity questionnaire (IPAQ) – short and long forms. [series online] 2005 [cited 2020 Dec 18]. Available from: URL: www.ipaq.ki.se
  15. Prahesti. Tingkat pengetahuan wanita usia subur tentang ovulasi dalam rangka program kehamilan di Desa Jenggrik Kecamatan Kedawung Kabupaten Sragen. Indones J Med Sci. 2016;3(2):94–9.
  16. Utami RF, Jeem YA, Mujiyanto, Prabowo BA. Hubungan lingkar perut dengan profil lipid terhadap kejadian prediabetes di Yogyakarta. Proceeding Book Call for Paper Thalamus: Medical Research for Better Health in Pandemic; 2020 Desember; Fakultas Kedokteran Universitas Muhammadiyah Surakarta.
  17. Kurnaeni N. Gambaran profil lipid pada obesitas perempuan. Jurnal Riset Kesehatan. 2013;6(4):218–22.
  18. Putri SR, Anggraini DI. Obesitas sebagai faktor resiko peningkatan kadar trigliserida. Medical Journal of Lampung University. 2015;4(9):78–82.
  19. Mamuaja CF. Lipida. 1st ed. Manado: Unsrat Press; 2017.
  20. Nazarina N, Christijani R, Sari YD. Faktor-faktor yang berhubungan dengan kadar malondialdehyde plasma pada penyandang diabetes mellitus tipe 2. Jurnal Gizi Klinik Indonesisa. 2013;9(3):139–46. doi: 10.22146/ijcn.15447
  21. Murray RK, Granner DK, Rodwell VW. Biokimia Harper. 30th ed. Jakarta: Buku Kedokteran EGC; 2017.
  22. Ahmed S, Shah P, Ahmed O. Biochemistry, lipids. [series online] 2021 [cited 2021 Sep 7]. Available from: URL: http://www.ncbi.nlm.nih.gov/books/NBK525952/
  23. Hussain A, Ali I, Kaleem WA, Yasmeen F. Correlation between body mass index and lipid profile in patients with type 2 diabetes attending a tertiary care hospital in Peshawar. Pak J Med Sci. 2019;35(3):591–7. doi: 10.12669/pjms.35.3.7
  24. Sudikno S, Syarief H, Dwiriani C, Riyadi H, Pradono J. Hubungan obesitas sentral dengan profil lipid pada orang dewasa umur 25-65 tahun di Kota Bogor (Baseline studi penyakit tidak menular di Kota Bogor, Jawa Barat). Jurnal Gizi Indonesia. 2016;39(2):81–92. doi: 10.36457/gizindo.v39i2.211
  25. Özkaya İ, Bavunoglu I, Tunçkale A. Body mass index and waist circumference affect lipid parameters negatively in Turkish Women. Am J Public Health Res. 2014;2(6):226–31.
  26. Gayatri B, Vinodhini VM. Correlation of lipids and lipoprotein concentration with body mass index in obese, overweight and normal weight south Indian adults. Int J Res Med Sci. 2017;5(11):4803–7. doi: 10.18203/2320-6012.ijrms20174923
  27. Feingold KR. Introduction to lipids and lipoproteins. [series online] 2000 [cited 2021 Sep 7]. Available from: URL: http://www.ncbi.nlm.nih.gov/books/NBK305896/



DOI: https://doi.org/10.22146/ijcn.69245

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