Efek kombinasi vitamin B1, B6, B12 untuk menurunkan intensitas nyeri pada penderita neuropatik diabetes

https://doi.org/10.22146/ijcn.26975

Rizaldy Taslim Pinzon(1*), Jesisca Jesisca(2)

(1) Fakultas Kedokteran Universitas Kristen Duta Wacana
(2) Fakultas Kedokteran Universitas Kristen Duta Wacana
(*) Corresponding Author

Abstract


Background: Neuropathy diabetic pain are common symptom in patient with diabetic melitus. The combination of vitamin B1, vitamin B6, and vitamin B12 usually used for treatment the pain, the result of previous studies are limited and conflicting.

Objective: The aim of the study to measure the convering of intensity of pain in diabetic neuropathy.

Method: The method of study using quase experimental design with pre and post treatment patient were selected by conservative sampling method from Bethesda Hospital, Yogyakarta. There are 68 patient diabetic neuropathy to follow in the study. Fact patient received combination of vitamin B1 100 mg, vitamin B6 100 mg, and vitamin B12 5000 mcg once a day for 3 month. Pain intensity measured using visual analog scale (VAS) on the first initial visited after 30th day and 90th day.

Results: The 68 patient consist of 27 (39.7%) male and 41 (60.3%) women. The mean age 58.32±6.72 years. The mean duration of Diabetic 4.32±2.86 year. The study showed that the pain intensity lower significantly after received vitamin B (p<0.001). The mean pain intensity in first VAS 43.68±12.32 lower to 20.42±11.24 and in the end of study lower to 12.23±8.39.

Conclusion: The combination of vitamin B1, B6, B12 significantly lower pain intensity of patient diabetic neuropathy.


Keywords


combination vitamin B1, B6 and B12; neuropathy peripherol diabetic; pain intensity

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References

  1. International Diabetes Federation. IDF Diabetes Atlas 6th Edition. [series online] 2013 [cited 2015 Oct 29]. Available from: URL: http://idf.org/diabetesatlas
  2. Purwanti OS. Analisis faktor-faktor risiko terjadinya ulkus kaki pada pasien diabetes mellitus di RSUD DR. Moewardi Surakarta [Thesis]. Jakarta: Universitas Indonesia; 2013.
  3. Schmader KE. Epidemiology and impact on quality of life of postherpetic neuralgia and painful diabetic neuropathy. Clin J Pain 2002;18(6):350-4.
  4. Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA. A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care 1994;17(11):1281-9.
  5. Bril V, Perkins BA. Validation of the Toronto clinical scoring system for diabetic polyneuropathy. Diabetes Care 2002;25(11):2048-52.
  6. Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res 2011;63(S11):S240-52.
  7. International Association for the Study of Pain. IASP Taxonomy. [series online] 2014 [cited 2015 May 25]. Available from: URL: http://www.iasp-pain.org/Taxonomy
  8. Elson M, Haas MD. Experpted from staying healthy with nutrition: the complete guide to diet and nutritional medicine in Wellness Journal: pyridoxine has a wide variety of metabolic functions in the body. [series online] 2007 [cited 2015 Nov 21]. Available from: URL: http://www.wellnessjournal.net/
  9. Thakkar K, Billa G. Treatment of vitamin B12 deficiency-methylcobalamine? cyancobalamine? hydroxocobalamin?-clearing the confusion. Eur J Clin Nutr 2014;69(1):1-2.
  10. Rizvi A, Ahmad A, Rizvi Z. Efficacy of combination of vitamin B1, B6 and B12 in management of diabetic peripheral neuropathy. [series online] 2013 [cited 2015 Oct 26]. Available from: URL: http://pjmhsonline.com/JulySept2013/efficacy_of_combination_of_vitamin_B1B6,b12.htm
  11. Mira W, Eka W, Indrasari U, Oka A. Neuropathic pain correlated with poor sleep quality in the elderly. Bali: Neurology Department, Faculty of Medicine, Udayana University/Sanglah General Hospital; 2015.
  12. Swenson R. Disorders of the nervous system. [series online] 2008 [cited 2015 Nov 20]. Available from: URL: https://www.dartmouth.edu/~dons/part_2/chapter_19.html
  13. Wandner LD, Scipio CD, Hirsh AT, Torres CA, Robinson ME. The perception of pain in others: how gender, race, and age influence pain expectations. J Pain 2012;13(3):220-7.
  14. Oberle K, Paul P, Wry J, Grace M. Pain, anxiety and analgesics: a comparative-study of elderly and younger surgical patients. Canadian Journal on Aging 1990;9(1):13-22.
  15. Davies M, Brophy S, Williams R, Taylor. The prevalence, severity, and impact painful diabetic peripheral neuropathy in type 2 diabetes. Diabetes Care 2006;29(7):1518-22.
  16. Sudoyo AW, Setiyohadi B, Alwi I. Buku ajar ilmu penyakit dalam; Jilid III. Edisi V. Jakarta: Interna Publishing; 2009.
  17. Cramer JA. A systematic review of adherence with medications for diabetes. Diabetes Care 2004;27:1218-24.
  18. Bell DSH. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J 2010;103(3):265-7.
  19. Kesavadev J, Das AK, Unnikrishnan R, Joshi SR, Ramachandran A, Mohan V, et al. Use of insulin pumps in India: suggested guidelines based on experience and cultural differences. Diabetes Technol Ther 2010;12(10):823-31.
  20. Mitchell BD, Hawthorne VM, Vinik AI. Cigarette smoking and neuropathy in diabetic patients. Diabetes Care 1990;13:434-7.
  21. Harris M, Eastman R, Cowie C. Symptoms of sensory neuropathy in adults with NIDDM in the U.S. population. Diabetes Care 1993;16:1446-52.
  22. Tamer A, Yildiz S, Yildiz N, Kanat M, Gunduz H, Celebi H, et al. The prevalence of neuropathy and relationship with risk factors in diabetic patients: a single-center experience. Med Princ Pract 2006;15(3):190-4.
  23. Schutta MH. Diabetes and hypertension: epidemiology of the relationship and pathophysiology of factors associated with these comorbid conditions. J Cardiometab Syndr 2007;2(2):124-30.
  24. Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005;54:1615-25
  25. Veves A, Backonja M, Malik RA. Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options. Pain Med 2008;9(6):660-74.
  26. Vallianou N, Evangelopoulos A, Koutalas P. Alpha-lipoic acid and diabetic neuropathy. Rev Diabet Stud 2010;6(4):230-6.



DOI: https://doi.org/10.22146/ijcn.26975

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