The Association Between Physical Activity and Monocyte-HDL Ratio in Diabetes Mellitus Patients Who Have Exceed Life Expectancy in Yogyakarta Province
Gibran Ilham Setiawan(1), Probosuseno Probosuseno(2*), Hemi Sinorita(3)
(1) Internal Medicine Specialist Program, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Sardjito Hospital
(2) Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Sardjito Hospital
(3) Division of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Sardjito Hospital
(*) Corresponding Author
Abstract
Background: The elderly population is expected to double in the upcoming three decades, due to increase in life expectancy. The province of DIY has the highest life expectancy in Indonesia (73.13 years and 76.67 years for men and women). Physical activity can reduce insulin resistance, improve lipid metabolism and reduce levels of inflammation in diabetes mellitus (DM). Physical activity can increase life expectancy. Many factors affect life expectancy, one of which is physical activity. This study investigated the association between physical activity and monocyte to HDL ratio (MHR) in diabetes mellitus patients who had exceeded their life expectancy in Yogyakarta.
Method: This cross-sectional study was conducted in September 2022-April 2023 and using purposive sampling. Participants who meet the criteria and consent were asked to fast at least 8 hours, then be interviewed by a physical activity questionnaire and checked complete blood tests, fasting blood glucose and HDL cholesterol. The association between physical activity and MHR then analyzed using SPSS.
Result: There were 50 participants with median age 78 (74-91) years. The mean score of physical activity is 100.28±7.96. Mean MHR is 0.0147±0.005. There is a significant relationship with weak correlation between physical activity and MHR (p 0.034, r -0.301), weak correlation between MHR and body mass index (BMI) (p 0.015, r 0.343), obesity (p 0.019, r 0.331) central obesity (p 0.032, r 0.303) and smoking (p 0.039, r 0.293). Multivariate analysis was performed, there is a significant relationship with weak correlation between physical activity and MHR (p 0.033, r -0.297).
Conclusion: There is a negative correlation with weak strength between physical activity and MHR in patients with diabetes mellitus who have reached the life expectancy of province of DIY.
Keywords
References
United Nations, Department of Economic and Social Affairs, Population Division (2019). World Population Ageing 2019: Highlights (ST/ESA/SER.A/430).
World Data. (2018). Average life expectancy by country. World Data. URL https://www.worlddata.info/life-expectancy.php. Diakses pada 12 Oktober 2021
Badan Pusat Statistik. (2020). Angka Harapan Hidup Menurut Provinsi dan Jenis Kelamin (Tahun), 2018 - 2020. https://www.bps.go.id/indicator/40/501/1/angka-harapan-hidup-ahh-menurut-provinsi-dan-jenis-kelamin. html. diakses pada 16 Oktober 2021
Badan Pusat Statistik (BPS). (2021). Indeks Kebahagiaan Tahun 2021. https://www.bps.go.id/publication/2021/12/27/ba1b0f03770569b5ac3ef58e/indeks-kebahagiaan-2021.html. Diakses 19 Desember 2021
Einarson, T.R., Acs, A., Ludwig, C., Panton, U.H. (2018). Prevalence of cardiovascular disease in type 2 diabetes : a systematic literature review of scientific evidence from across the world in 2007 – 2017. Cardiovasc Diabetol 1–19.
Yang, P., Feng, J., Peng, Q., Liu, X., Fan, Z., Luca, M. (2019). Advanced Glycation End Products: Potential Mechanism and Therapeutic Target in Cardiovascular Complications under Diabetes. Oxid Med Cell Longev :9570616. doi: 10.1155/2019/9570616.
Tachkov, K., Mitov, K., Koleva, Y., Mitkova, Z., Kamusheva, M., Dimitrova, M., Petkova, V., Savova, A., Doneva, M., Tcarukciev, D. et al. (2020). Life expectancy and survival analysis of patients with diabetes compared to the non diabetic population in Bulgaria. PloS one, 15(5), e0232815. https://doi.org/10.1371/journal.pone.0232815
Franceschi C. & Campisi J. (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. doi: 10.1093/gerona/glu057. PMID: 24833586.
Washburn, RA., Smith, KW., Jette, AM., Janney, CA. (1993) The Physical Activity Scale for the Elderly (PASE): development and evaluation. J Clin Epidemiol ;46(2):153-62. doi: 10.1016/0895-4356(93)90053-4
Hagiwara, A., Ito, N., Sawai, K., Kazuma, K. (2008) Validity and reliability of the Physical Activity Scale for the Elderly (PASE) in Japanese elderly people. Geriatrics & Gerontology International. Sep 1;8(3):143–51
Harada, ND., Chiu V., King, AC., Stewart, L. (2001). An Evaluation of three self-report Physical Activity instruments for older Adults. Med Sci Sport Exercise. 33(6) :962-70. DOI: 10.1097/00005768-200106000-00016
Ngai S., Cheung R., Lam P., Chiu J., Fung E. (2012) Validation and Reliability of the PASE in chinese population. J Rehabil Med. 44(5);462-5
Covotta A., Gagliardi M., Berardi A., Maggi G., Perelli F., Mollica R., et al (2018). Physical Activity Scale for Elderly: Translation, Cultural Adaptation ,and Validation of the Italian version. Curr Gerontol Geriatr Res, 1-7
Norliana I., Hairi F., Wan Yuen C., Noran Naqiah H., Peramalah D., Bulgida A. (2015) The Physical Activity Scal for Elderly (PASE) valiity and reliability among community dwelling older adults in Malaysia. Asia Pac J Public Health, 27(85);625-725
Yılmaz, M. (2018). A New Inflammatory Marker : Elevated Monocyte to HDL Cholesterol Ratio Associated with Smoking. J Clin Med, 10;7(4):76. doi: 10.3390/jcm7040076.
Wu, T., Zheng, Y., Chen, Y., Yu, Z., Ma, Y., Xie, X. (2019). Monocyte to high-density lipoprotein cholesterol ratio as long-term prognostic marker in patients with coronary artery disease undergoing percutaneous coronary intervention. Lipids Health Dis ; 18: 180. doi: 10.1186/s12944-019-1116-2
Hamer, M., Lavoie, K., Bacon, S. (2014). Taking up physical activity in later life and healthy ageing: the English longitudinal study of ageing. Br J Sports Med Feb;48(3):239-43
Ruiz-Raime, J. J., Barber, J. L., & Sarzynski, M. A. (2019). Effects of exercise on HDL functionality. Current Opinion in Lipidology, 30(1), pp. 16-23. doi : 10.1097/MOL.0000000000000568
Qasim, A. N., Budharaju, V., Mehta, N. N., St Clair, C., Farouk, S., Braunstein, S., Schutta, M., Iqbal, N., Rader, D. J., & Reilly, M. P. (2011). Genderdifferences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes. Clinical endocrinology, 74(1), 44–50. https://doi.org/10.1111/j.1365-2265.2010.03879.x
Milan-Mattos, J. C., Anibal, F. F., Perseguini, N. M., Minatel, V., Rehder-Santos,P., Castro, C. A., Vasilceac, F. A., Mattiello, S. M., Faccioli, L. H., & Catai, A. M. (2019). Effects of natural aging and gender on pro-inflammatory markers. Brazilian journal of medical and biological research/Revista brasileira de pesquisas medicas e biologicas, 52(9), e8392. https://doi.org/10.1590/1414-431X20198392
Stefanska, A., Bergmann, K., Sypniewska, G. (2015). Metabolic Syndrome and Menopause : Pathophysiology , Clinical and Diagnostic Significance. Adv Clin Chem ;72:1-75. doi: 10.1016/bs.acc.2015.07.001. Epub 2015 Aug 21.
Onalan, E., (2019). The relationship between monocyte to high-density lipoprotein cholesterol ratio and diabetic nephropathy. Pak J Med Sci ;35(4):1081-1086. doi: https://doi.org/10.12669/pjms.35.4.534
Gembillo, G., Siligato, R., Cernano, V., Satta, E., Conti, G., Salvo, A et al. (2021). Monocyte to HDL ratio: a novel marker of resistant hypertension in CKD patients. International Urology and Nephrology. doi : https://doi.org/100.1007/s11255-021-02904-9
Aslan I., Kucuksayan E., Aslan M. (2013) Effect of Insulin analog initiation therapy on LDL/HDL subfraction profile and HDL associated enzymes in type 2 diabetic patient. Lipids in Health and Disease. 12:54.
Battaglia, S., Scialpi, N., Berardi, E., Antonica, G., Suppressa, P., Diella, F. A., Colapietro, F., Ruggieri, R., Guglielmini, G., Noia, A., Graziano, G., Sabbà, C., & Cariello, M. (2020). Gender, BMI and fasting hyperglycaemia influence Monocyte to-HDL ratio (MHR) index in metabolic subjects. PloS one, 15(4), e0231927. https://doi.org/10.1371/journal.pone.0231927
Elisia, I., Lam, V., Cho,B., Hay, M., Yu, M., Yeung, M., et al.(2020). The effect of smoking on chronic inflammation, immune function and blood cell composition. Sci Rep. 10: 19480. doi: 10.1038/s41598-020-76556-7
Smith, C., Kluck, L., Ruan, G., Ashrani, A., Marshall, A., Pruthi, R., et al. (2020). Leukocytosis and Tobacco Use : An observational Study of Asymptomtic Leukocytosis. The American Journal of Medicine doi : https://doi.org/10.1016/j.amjmed.2020.06.014
Tulgar, Y., K., Cakar, S., Tulgar, S., Dalkilic,O., Cakiroglu, B., Uyanikl, B. (2016). The effect of smoking on neutrophil/lymphocyte and platelet/lymphocyte ratio and platelet indices: a retrospective. Eur. Rev. Med. Pharmacol. Sci. 20, 3112–3118
Uslu, A.U., Sekin, Y., Tarhan, G., Canakcı, N., Gunduz, M., Karagulle, M. (2018). Evaluation of Monocyte to High-Density Lipoprotein Cholesterol Ratio in the Presence and Severity of Metabolic Syndrome. Clinical and Applied Thrombosis/Hemostasis 24, 828–833.
Jialal, I., Jialal, G., Adams-Huet, B., Ramakrishnan, N. (2020). Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome. Horm Mol Biol Clin Investig 41.
Soelistijo, A.S., Suastika, K., Lindarto, D., Decroli, E., et al. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Jakarta: PB PERKENI
Doubova, S. v., Sánchez-García, S., Infante-Castañeda, C., Pérez-Cuevas, R.. (2016). Factors associated with regular physical exercise and consumption of fruits and vegetables among Mexican older adults. BMC Public Health 16.
Gopinath, B., Kifley, A., Flood, V.M., Mitchell, P. (2018). Physical Activity as a Determinant of Successful Aging over Ten Years. Sci Rep 8.
Kitreerawutiwong, N., Keeratisiroj, O., Mekrungrongwong, S. (2021). Factors That Influence Physical Activity Among Older Adults Living in Rural Community in Wangthong District, Phitsanulok, Thailand. Sage Open ;11 (4). doi : https://doi.org/10.1177/2158244021106136
Liangruenrom, N., Craike, M., Biddle, S.J.H., Suttikasem, K., Pedisic, Z. (2019). Correlates of physical activity and sedentary behaviour in the Thai population: A systematic review. BMC Public Health.
New England Research Institute (NERI). (1991). Physical activity scale for the elderly (PASE). http://www.neri.org. Diakses pada 11 November 2021
Washburn RA., McAuley, E., Katula ,J., Mihalko, SL., Boileau, RA. (1999). The Physical Activity Scale for the Elderly (PASE): Evidence for Validity, . J Clin Epidemiol ;52(7):643-51. doi: https://doi.org/10.1016/S0895-4356(99)00049-9
Notthoff, N., Reisch, P., Gerstorf, D. (2017). Individual Characteristics and Physical Activity in Older Adults: A Systematic Review. Gerontology ;63(5):443-459. doi: 10.1159/000475558. Epub 2017 Jul 5.
Annisa, B.B. (2015). Hubungan Aktivitas Fisik dengan Kejadian Retinopati Diabetika pada Pasien Diabetes Mellitus Tipe 2: Jogjakarta Eye Diabetic Study in the Community. https://etd.repository.ugm.ac.id/penelitian/detail/89462
De Borba, AT., Gas,R., Nedel,F., Jost, R.(2014). The influence of active and passive smoking on the cardiorespiratory fitness of adults. Multidisciplinary Respiratory Medicine 9(1):34
Silveira, E.A., Pereira, C.C., Pagotto, V., Oliveira, C. (2022). Low muscle mass and mortality risk later in life: A 10-year follow-up study. PLoS One Jul 28;17(7)
Kujala, U.M. (2018). Is physical activity a cause of longevity? It is not as straightforward as some would believe. A critical analysis. Br J Sports Med Jul;52(14):914-918
Hayashino, Y., Jackson, J.L., Fukumori, N., Nakamura, F., Fukuhara, S. (2012). Effects of supervised exercise on lipid profiles and blood pressure control in people with type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Diabetes Res Clin Pract Dec;98(3):349-60
DOI: https://doi.org/10.22146/actainterna.101284
Article Metrics
Abstract views : 16Refbacks
- There are currently no refbacks.
Copyright (c) 2024 Acta Interna: The Journal of Internal Medicine
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Acta Interna The Journal of Internal Medicine Indexed by:
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.