The Effect of SiO 2  Addition to the Hydroxyapatite/Curcumin Composite Properties

Tri Windarti; Nor Basid Adiwibawa Prasetya; Ngadiwiyana Ngadiwiyana

doi:10.22146/ijc.93802

The Effect of SiO₂ Addition to the Hydroxyapatite/Curcumin Composite Properties

https://doi.org/10.22146/ijc.93802

Tri Windarti^(1*), Nor Basid Adiwibawa Prasetya⁽²⁾, Ngadiwiyana Ngadiwiyana⁽³⁾

(1) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(2) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(3) Department of Chemistry, Faculty of Science and Mathematics, Universitas Diponegoro, Jl. Prof. Soedharto SH, Tembalang, Semarang 50275, Indonesia
(*) Corresponding Author

Abstract

Hydroxyapatite/curcumin composites have been studied as a calcium phosphate cement candidate. In this research, the effects of adding SiO₂ to the hydroxyapatite/curcumin composite on the characteristics of the cement, such as the crystal and surface properties, as well as the release behavior of curcumin in Ringer's solution media, were studied. The composite preparation with and without SiO₂ was carried out using a Na₂HPO₄ 2.5% solution. The results showed that the addition of 25% SiO₂ to the hydroxyapatite/curcumin composite did not change the crystal properties of hydroxyapatite but produced a more homogenous distribution of the ingredients. The behavior of the composite in Ringer's solution also changes, which is proven by the change in the crystal growth direction and Ca/P ratio. Adding SiO₂ produced a composite with a platter and larger particles, as well as a higher Ca/P ratio on the surface. The presence of SiO₂ inhibited the release of curcumin in which the ratio of HA: curcumin changed from 77.7%:22.3% to 69.6%:30.4% after 5 d of immersion in Ringer's solution. Thus, besides increasing calcium phosphate deposition on the cement surface, SiO₂ also prevents curcumin from being released from the composite.

Keywords

hydroxyapatite; curcumin; SiO2; calcium phosphate cement

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DOI: https://doi.org/10.22146/ijc.93802