Synthesis, Structural Determination and Antibacterial Properties of Zinc(II) Complexes Containing 4-Aminopyridine Ligands

I Wayan Dasna; Dewi Mariyam; Husni Wahyu Wijaya; Ubed Sonai Fahruddin Arrozi; Sugiarto Sugiarto

doi:10.22146/ijc.82801

Synthesis, Structural Determination and Antibacterial Properties of Zinc(II) Complexes Containing 4-Aminopyridine Ligands

https://doi.org/10.22146/ijc.82801

I Wayan Dasna^(1*), Dewi Mariyam⁽²⁾, Husni Wahyu Wijaya⁽³⁾, Ubed Sonai Fahruddin Arrozi⁽⁴⁾, Sugiarto Sugiarto⁽⁵⁾

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia; Center of Advanced Material for Renewable Energy, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia; Center of Advanced Material for Renewable Energy, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Jl. Semarang No. 5, Malang 65145, East Java, Indonesia
(5) Department of Applied Chemistry, Graduate School of Advanced Science and Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 7398527, Japan
(*) Corresponding Author

Abstract

Three zinc(II) complexes containing 4-aminopyridine (4-NH₂py) [Zn(4-NH₂py)₂(NCS)₂] (1), [Zn(4-NH₂py)₂Cl₂] (2), and [Zn(4-NH₂py)₂(NCS)Cl] (3) were synthesized and characterized by FTIR and single crystal X-ray diffraction. All complexes adopt a slightly distorted tetrahedral geometry with different crystal packing. Complex 1 crystallizes in the orthorhombic Pmmn space group, complex 2 in the monoclinic C2/c space group, and complex 3 in the orthorhombic Pbca space group. Non-covalent interactions such as NC-S···H, -Cl···H, and µ-µ stacking interaction between 4-NH₂py and other ligands (NCS⁻ and Cl⁻) are observed in the crystals packing. In vitro, antibacterial screening of all complexes was evaluated against two bacteria (Escherichia coli and Staphylococcus aureus). The results show that 1 has the highest antibacterial activity than 2 and 3. This difference is due to differences in the interactions elicited by the anion ligands.

Keywords

zinc(II) complexes; 4-NH2py; thiocyanato; chloro ligand; antibacterial activity

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DOI: https://doi.org/10.22146/ijc.82801