Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells

Fattima Al-Zahra Gabar Gassim; Ali Jabbar Jasim Makkawi

doi:10.22146/ijc.76872

Anticancer Activity of Synthesized ZnO and ZnO/AgCl Nanocomposites against Five Human Cancer Cells

https://doi.org/10.22146/ijc.76872

Fattima Al-Zahra Gabar Gassim^(1*), Ali Jabbar Jasim Makkawi⁽²⁾

(1) Department of Pharmaceuticals, College of Pharmacy, University of Babylon, Hilla 51002, Iraq
(2) Department of Chemistry, College of Science, University of Babylon, Ministry of Education, Hilla 51002, Iraq
(*) Corresponding Author

Abstract

In this work, a refluxing method is used to prepare nanoparticles of zinc oxide (ZnO NPS) and zinc oxide /silver chloride nanocomposites (ZnO/AgCl NCS). The structural properties of nanocrystals are studied by Atomic Force Microscope (AFM), X-Ray Diffraction (XRD), and Field Emission Scanning Electron Microscopy (FE-SEM) to determine the average crystal size, morphology, particle size and average grain size of nanocrystals. The results of anticancer efficiency of ZnO NPs and ZnO/AgCl NCs show cytotoxic activity against five human cancer cells, namely hepatocellular carcinoma, rhabdomyosarcoma (RD), colorectal carcinoma (HCT116), mammary gland (MCF-7), and epidermoid carcinoma (Hep2) compared against doxorubicin. The anticancer mechanism of pure and nanocomposites ZnO are suggested according to the release of Zn⁺² and the production of reactive oxidation species (ROS) and the effect of these species on cancer inhibition.

Keywords

ZnO nanoparticles; the anticancer activity of nanoparticles; ZnO/AgCl nanocomposites

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References

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DOI: https://doi.org/10.22146/ijc.76872