Assessment of the Level and Health Risk of Fluoride and Heavy Metals in Commercial Toothpastes in Bangladesh
Chanchal Chayan Paul(1), Md. Abu Shamim Khan(2), Probir Kumar Sarkar(3), Abdul Hakim(4), Md. Waliullah(5), Bablu Hira Mandal(6*)
(1) Department of Chemical Engineering, Jashore University of Science and Technology, Jashore-7408, Bangladesh
(2) Environmental Laboratory, Asia Arsenic Network, Jashore, Bangladesh
(3) Department of Chemical Engineering, Jashore University of Science and Technology, Jashore-7408, Bangladesh
(4) Environmental Laboratory, Asia Arsenic Network, Jashore, Bangladesh
(5) Environmental Laboratory, Asia Arsenic Network, Jashore, Bangladesh
(6) Department of Chemistry, Jashore University of Science and Technology, Jashore-7408, Bangladesh
(*) Corresponding Author
Abstract
Toothpaste is one of the daily essentials, and good quality control practices over it are very important to protect the oral public health from adverse effects. The current study aimed to assess the concentration of fluoride and heavy metals, physicochemical properties in ten different toothpaste samples in Bangladesh, followed by related health risk analysis. pH, moisture content, F–, As, Cu, Pb contents were measured by membrane electrode, thermogravimetric, SPADNS, HG-AAS, flame-AAS methods, respectively. The results were compared to the specification of the packet and Bangladesh Standard and Testing Institute (BSTI) standard. The physicochemical properties well-matched the formulation standard values. The moisture content was 27.18 ± 2.20 to 52.10 ± 5.01%, with 50% of the samples in permissible limit but the pH of all the samples (6.40-8.60) was within the standard limit. Available F–, Cu, Pb, and As content ranged from 803–1617, 2.78–13.10, 0.27–2.12, and 0.027–0.637 mg/Kg, respectively. F– content in 80% toothpaste did not meet the packet specification and was higher than BSTI standard, though heavy metals were within the BSTI limit. Hazard quotient (HQ) and HI (Hazard Index) analysis revealed that toothpaste safe from heavy metal related to health risk.
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[1] Burt, B.A., 1998, Prevention policies in the light of the changed distribution of dental caries, Acta Odontol. Scand., 56 (3), 179–186.
[2] Safra, J.E., Constantine, S.Y., and Goulk, J.E., 1998, The New Encyclopedia Britannica, 15th Ed., Encyclopedia Britannica, Inc., London UK, 2, 356; 7, 678; 10, 931; 14, 547; 17, 293, 259; 20, 513; 25, 55-56, 61, 68; 26, 846; 28, 307.
[3] Ivanova, M., and Christova, R., 1995, Potentiometric determination of fluorine in dentifrices of high ionic level, Anal. Lab., 4, 47–50.
[4] Carton, R.J., 2006, Review of the 2006 United States National Research Council report: Fluoride in drinking water, Fluoride, 39 (3), 163–172.
[5] Konieczka, P., Zygmunt, B., and Namieśnik, J., 2000, Effect of fluorine content in drinking water in ricity on its concentration in urine of pre-school children, Toxicol. Environ. Chem., 74 (2), 125–130.
[6] Odukudu, F.B., Ayenimo, J.G., Adekunle, A.S., Yusuff, A.M., and Mamba, B.B., 2014, Safety evaluation of heavy metal exposure from consumers, Int. J. Consum. Stud., 38 (1), 25–34.
[7] Sainio, E.L., and Kanerva, L., 1995, Contact allergens in toothpaste and a review of their hypersensitivity, Contact Dermatitis, 33 (2), 100–105.
[8] Waldbolt, G.L., 1998, The preskeletal phase of chronic fluoride intoxication, Fluoride, 31 (1), 13–20.
[9] Jordan, R.A., Markovich, L., Gaengler, P., and Zimmer, S., 2011, Total and free fluoride concentrations of African dentifrics marketed in West Africa, Oral Health Prev. Dent., 9 (1), 53–58.
[10] Oyewale, A.O., 2005, Estimation of essential inorganic constituents of commercial toothpaste, J. Sci. Ind. Res., 64 (2), 101–107.
[11] Ideriah, T.J.K., Obunwo, C.C., and Eretoru, T.D., 2016, Assessment of fluoride and heavy metals concentrations in toothpastes marketed in Port Harcourt Nigeria, Int. J. Adv. Innovative Res., 5 (5), 28–34.
[12] Teki, K., and Bhat, R., 2013, Estimation of the components in oral care products available in Indian market – Part II: Toothpaste, Int. J. Pharm. Chem. Sci., 2 (2), 705–712.
[13] Benzian, H., Holmgren, C., Buijs, M., van Loveren, C., van der Weijden, F., and van Palenstein Helderman, W., 2012, Total and free available fluoride in toothpastes in Brunei, Cambodia, Laos, the Netherlands and Suriname, Int. Dent. J., 62 (4), 213–221.
[14] de Freitas, J.F., 1984, Fluoride stability in toothpastes, Aust. Dent. J., 29 (1), 30–35.
[15] Hashizume, L.N., de Oliveira Lima, Y.B., Kawaguchi, Y., and Cury, J.A., 2003, Fluoride availability and stability of Japanese dentifrices, J. Oral Sci., 45 (4), 193–199.
[16] Thakkar, V.P., Rao, A., Rajesh, G., Shenoy, R., and Pai, M., 2015, Fluoride content and labeling of toothpastes marketed in India, Community Dent. Health, 32 (3), 170–173.
[17] Ko, H.Y., Kang, S.M., Kwon, H.K., and Kim, B.I., 2015, Evaluation of fluoride bioavailability in toothpastes, J. Korean Acad. Oral Health, 39 (2), 81–87.
[18] Krishna, D.G., Al-Amri, S.H., Al-Mamari, F.S., Al-Sidairi, A.S., and Devi, C.K., 2015, Estimation of the essential inorganic constituents of various commercial toothpastes, Int. J. Inorg. Bioinorg. Chem., 5 (1), 14–15.
[19] Anju, T., and Aiswarya, K., 2016, Formulation and antimicrobial evaluation of Toothpastes containing arginine and proline, Int. J. Adv. Pharm., Biol. Chem., 5 (2), 143–147.
[20] Prasanna, S.G.V., Abllasha, R., and Gopinath, 2016, In vitro comparison of antimicrobial efficacy of different toothpaste, J. Pharm. Sci. Res., 8 (10), 1195–1198.
[21] Rao, R.N., and Rao, T.N., 2014, Determination heavy metals in toothpastes containing tin as an ingredient, Indian J. Chem. Tehnol., 21 (4), 238–243.
[22] Mohod, C.V., and Dhote, J., 2013, Review of heavy metals in drinking water and their effect on human health, Int. J. Innovative Res., Sci. Eng. Technol., 2 (7), 2992–2996.
[23] Kawata, K., Yokoo, H., Shimazaki, R., and Okabe, S., 2007, Classification of heavy metal toxicity by human DNA microarray analysis, Environ. Sci. Technol., 41 (10), 3769–3774.
[24] Järup, L., 2003, Hazards of heavy metal contamination, Br. Med. Bull., 68 (1), 167–182.
[25] Chien, L.C., Hung, T.C., Choang, K.Y., Yeh, C.Y., Meng, P.J., Shieh, M.J., and Han, B.C., 2002, Daily intake TBT, Cu, Zn, Cd and As for fisherman in Taiwan, Sci. Total Environ., 285 (1-3), 177–185.
[26] Food and Nutrition Board, 2004, Dietary reference intakes (DRIs): Recommended intakes for individuals, Institute of Medicine, US National Academies, Washington DC, United States.
[27] Gharaibeh, A.A., El-Rjoob, A.O., and Harb, M.K., 2010, Determination of selected heavy metals in air samples from the northern part of Jordan, Environ. Monit. Assess., 160 (1-4), 425–429.
[28] Pandey, J., Pandey, R., and Shubhashish, K., 2009, Air-borne heavy metal contamination to dietary vegetables: A case study from India, Bull. Environ. Contam. Toxicol., 83 (6), 931–936.
[29] Fernandes, C., Fontaínhas-Fernandes, A., Cabral, D., and Salgado, M.A., 2008, Heavy metals in water, sediment and tissues of Liza saliens from Esmoriz–Paramos lagoon, Portugal, Environ. Monit. Assess., 136 (1-3), 267–275.
[30] Aguilar, C.A., Montalvo, C., Rodriguez, L., Ceron, J.G., and Ceron, R.M., 2012, American oyster (Crassostrea virginica) and sediments as a coastal zone pollution monitor by heavy metal, Int. J. Environ. Sci. Technol., 9 (4), 579–586.
[31] Salve, K.S., and Sonwane, N.S., 2015, Detection of heavy metals in cosmetics, World J. Pharm. Res., 4 (4), 1368–1372.
[32] Ayenimo, J.G., Yusuf, A.M., Adekunle, A.S., and Makinde, O.W., 2010, Heavy metal exposure from personal care products, Bull. Environ. Contam. Toxicol., 84 (1), 8–14.
[33] Bocca, B., Pino, A., Alimonti, A., and Forte, G., 2014, Toxic metals contained in cosmetics: A status report, Regul. Toxicol. Pharmacol., 68 (3), 447–467.
[34] Orisakwe, O.E., Okolo, K.O., Igweze, Z.N., Ajaezi, G.C., and Udowelle, N.A., 2016, Potential hazards of toxic metals found in toothpastes commonly used in Nigeria, Rocz. Panstw. Zakl. Hig., 67 (2), 197–204.
[35] American Public Health Association, 2005, Standard Methods for the Examination Water and Wastewater, 21st Ed., Eds. Eaton, A.D., Clesceri, L.S., Franson, M.A.H., Rice, E.W., and Greenberg, A.E., American Public Health Association, Washington DC, United States.
[36] Bangladesh Standard and Testing Institution (BSTI), 2001, Bangladesh Standard Specification for Tooth-paste, 1st revision, Bangladesh Standard and Testing Institution (BSTI), Dhaka, Bangladesh.
[37] Akelesh, T., Kumar, R.S., Jothi, R., Rajan, V., Arulraj, P., and Venkatnarayanan, R., 2010, Evaluation of standards of some selected cosmetic preparations, Asian J. Pharm. Res. Health Care, 2 (4), 302–306.
[38] United States Environmental Protection Agency (USEPA), 2007, Integrated risk information system-database, U.S. Environmental Protection Agency, Washington DC, United States.
[39] United States Environmental Protection Agency (USEPA), Office of Water Regulations and Standards, 1989, Assessing human health risks from chemically contaminated fish and shellfish: A guidance manual, U.S. Environmental Protection Agency, Washington DC, United States.
[40] WHO, 2010, Preventing disease through healthy environments – Inadequate or excess fluoride: A major public health concern, World Health Organization, Geneva.
[41] Petersen, P.E., and Lennon M.A., 2004, Effective use of fluorides for the prevention of dental caries in the 21st century: The WHO approach, Community Dent. Oral Epidemiol., 32 (5), 319–321.
[42] Abou-Arab, A.A., and Abou Donia, M.A., 2000, Heavy metals in Egyptian spices and medicinal plants and the effect of processing on their leaves, J. Agric. Food Chem., 48 (6), 2300–2304.
[43] Wu, J., Zou, Y., Zhan, X., Lu, G., and Lai, F., 2008, Survey of heavy metal pollution in four Chinese crude drugs and their cultivated soils, Bull. Environ. Contam. Toxicol., 81 (6), 571–573.
DOI: https://doi.org/10.22146/ijc.43266
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