Characterization of Semi-Interpenetrated Network Alginate/Gelatin Wound Dressing Crosslinked at Sol Phase

Dian Pribadi Perkasa; Erizal Erizal; Tri Purwanti; Alva Edy Tontowi

doi:10.22146/ijc.25710

Characterization of Semi-Interpenetrated Network Alginate/Gelatin Wound Dressing Crosslinked at Sol Phase

https://doi.org/10.22146/ijc.25710

Dian Pribadi Perkasa^(1*), Erizal Erizal⁽²⁾, Tri Purwanti⁽³⁾, Alva Edy Tontowi⁽⁴⁾

(1) Department of Radiation Processing, Center for Application of Isotopes and Radiation, National Nuclear Energy Agency
(2) Department of Radiation Processing, Center for Application of Isotopes and Radiation, National Nuclear Energy Agency
(3) Department of Work Safety and Mining Installation, Center for Nuclear Ore Technology, National Nuclear Energy Agency
(4) Department of Mechanical and Industrial Engineering, Faculty of Engineering, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Gel contraction of alginate during ionic crosslinking at sol phase was reduced by blending with gelatin solution due to intermolecular interaction and chain entanglement. The semi-interpenetrated network (semi-IPN) of wound dressing hydrogels were prepared by overlaid alginate/gelatin blend with 1.0% (w/w) CaCl₂ solution under ambient temperature for 2 h. Results showed that gel contraction was significantly reduced with increasing gelatin content i.e. from 40.5 ± 5.8% for pure alginate to as low as 5.8 ± 1.2% for alginate/gelatin of 1:7 (w/w). It seems that gelatin successfully inhibited alginate chains mobility during their network re-arrangement by Ca²⁺ cation. The FTIR spectra of hydrogels showed combination of characteristic vibration of alginate and gelatin. Increasing gelatin content also significantly improved elasticity and tensile strength at break of dried hydrogels. Swelling kinetics of dried hydrogels were fitted Schott’s second-order power-law model. Increasing gelatin fraction increased the swelling rate while decreased the swelling at equilibrium. Their absorptive capacity were of interval for management of moderate to heavily exudating wound.

Keywords

alginate/gelatin; wound dressing; gel contraction; swelling kinetic; biomedical engineering

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DOI: https://doi.org/10.22146/ijc.25710