6,6’-DIMETHOXY-4,4’-DIHYDROXY-3’,2’-FURANO-ISOFLAVANE, A NEW COMPOUND FROM Melochia umbellata (Houtt.) Stapf var. Degrabrata K. (Paliasa)
Erwin Erwin(1), Alfian Noor(2*), Nunuk Hariani Soekamto(3), Tjodi Harlim(4)
(1) Doctoral Programme in Chemistry, Post Graduate Programme, Hasanuddin University and Department of Chemistry, Mulawarman University, Kampus Gn. Kelua, 75123 Samarinda
(2) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(3) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(4) Department of Chemistry Hasanuddin University, Kampus UNHAS Tamalanrea, 90245 Makassar
(*) Corresponding Author
Abstract
Using data from UV, IR, 1H-NMR, 13C-NMR, dan NMR-2D analysis, a compound of 6,6'-dimethoxy-4,4'-dihydroxy-3',2'-furano-isoflavane (1) was successfully isolated from chloroform fraction of heartwood in Melochia umbellata (Houtt.) Stapf var. Degrabarata K (Paliasa). Hitherto no report of such compound found in literature. The compound however has not shown a significant bioactivity according to either brine shrimp lethality test or evaluation of anti tumor activity against leukemia murine cell (P-388).
Keywords
Full Text:
Full Text PDFReferences
[1] Tjitrosoepomo, G, 2004, Taksonomi Tumbuhan (Spermatophyta), Gajah Mada University Press, Yokyakarta, 274-275.
[2] Raflizar, Adimunca, C., and Tuminah, S., 2006, Cermin Dunia Kedokteran, 50, 10-14.
[3] Erwin, Noor, A., Soekamto, N.H., and Harlim, Tj., 2009, Ind. Chim. Acta, 2, 1, 22-30.
[4] Erwin, Noor, A., Soekamto, N.H., and Harlim, Tj., 2009, Kimia Mulawarman, 6, 2,7-10.
[5] Erwin, Noor, A, Soekamto, N.H., and Harlim, Tj., 2009, Farmakologi Jurnal Farmasi, IV, 2, 51-55.
[6] Meyer, B.N., Ferrigny, N.R., Putnam, J.E., Jacobsen, L.B., Nicols, D.E., and McLaughlin, J.L., 1982, J. Med. Plant Res., 45, 31-34.
[7] Alley, M.C., Scudiero, D.A., Monks, A., Hursey, M.L., Czerwinksky, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H., and Boyd, M.R., 1988, Cancer Res., 48, 589-601.
DOI: https://doi.org/10.22146/ijc.21463
Article Metrics
Abstract views : 1714 | views : 1183Copyright (c) 2010 Indonesian Journal of Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.
View The Statistics of Indones. J. Chem.