IN VITRO ACTIVITY AND COMPARATIVE STUDIES OF SOME ORGANOTIN(IV) BENZOATE DERIVATIVES AGAINST LEUKEMIA CANCER CELL, L-1210

https://doi.org/10.22146/ijc.21359

Sutopo Hadi(1*), Mita Rilyanti(2), Suharso Suharso(3)

(1) Department of Chemistry, University of Lampung, Bandar Lampung 35145
(2) Department of Chemistry, University of Lampung, Bandar Lampung 35145
(3) Department of Chemistry, University of Lampung, Bandar Lampung 35145
(*) Corresponding Author

Abstract


A series of dibutyl-, diphenyl- and triphenyltin(IV) benzoate derivatives has been prepared. The products were obtained by reacting the dibutyltin(IV) dichloride, diphenyltin(IV) dichloride and triphenyltin(IV) chloride respectively via the dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide and triphenyltin(IV) hydroxide with benzoate acid and its derivative. The targeted compounds have been tested with anticancer activity against leukemia cancer cell, L-1210. The compounds synthesized were well characterized by 1H and 13C NMR, IR and UV-Vis spectroscopies as well as based on the microanalytical data. The results showed that triphenyltin(IV) benzoate and its derivative prepared exhibit higher anticancer activity than those of dibutyltin(IV) and diphenyltin(IV) analogous.

Keywords


anticancer activity test; IC50; leukemia cancer cell; organotin(IV) benzoates

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References

[1] Nath, M., Pokharia, S., and Yadav, R., 2001, Coord. Chem. Rev., 215, 99–149.

[2] Gielen, M., 2003, J. Braz. Chem. Soc., 14, 6, 870–877.

[3] Zhang, Z-W., Jiang, T., Ren, S-M., Zhang, Y-X., and Yu, J-S., 2005, Chin. J. Chem., 23, 12, 1655–1658.

[4] Pellerito, L., and Nagy, L., 2002, Coord. Chem. Rev., 224, 111–150.

[5] Bonire, J.J., Ayoko, G.A., Olurinola, P.F., Ehinmidu, J.O., Jalil, N.S.N., and Omachi, A.A., 1998, Met.-Based Drugs, 5, 4, 233–236.

[6] Mahmood, S., Ali, S., Bhatti, M.H., Mazhar, M., and Iqbal, R., 2003, Turk. J. Chem., 27, 6, 657–666.

[7] Li, Y., Li, Y., Niu, Y., Jie, L., Shang, X., Guo, J., and Li, Q., 2008, J. Bioinorg. Chem., 102, 9, 1731–1735.

[8] Rehman, W., Badshah, A., Khan, S., and Tuyet, L.T.A., 2009, Eur. J. Med. Chem., 44, 10, 3981–3985.

[9] Hadi, S., and Rilyanti, M., 2010, Orient. J. Chem., 26, 3, 775–779.

[10] Ruzika, A., Dostal, L., Jambor, R., Butcha, V., Brus, J., Cisarova, I., Holcapek, M., and Holecek, J., 2002, Appl. Organomet. Chem., 16, 6, 315–322.

[11] Hadi, S., Irawan, B., and Efri, 2008, J. Appl. Sci. Res., 4, 11, 1521–1525.

[12] Hadi, S., Rilyanti, M., and Nurhasanah, 2009, Mod. Appl. Sci., 3, 1, 12–17.

[13] Szorcsik, A., Nagy, L., Gadja-Schrantz, K., Pellerito, L., Nagy, E., and Edelmann, E.T., 2002, J. Radioanal. Nucl. Chem., 252, 3, 523–530.

[14] Turner, R.A., 1972, Screening Methods In Pharmacology, New York, Academic Press, 60–72.

[15] Nath, M., Yadav, R., Gielen, M., Dalil, H., de Vos, D., and Eng, G., 1997, Appl. Organomet.. Chem., 11, 727–736.

[16] Li, Q., da Silva, F.M.C.G., and Pombeiro, A.J.L., 2004, Chem. Eur. J., 10, 6, 1456–1462.

[17] Sudjadi, 1985, The Structure Determination of Organic Compounds, Ghalia Publishers, Indonesian, 327.

[18] Chohan, Z.H., and Rauf, A., 1996, Synth. React. Inorg. Met.-Org. Chem., 26, 4, 591–604.

[19] Gershon, H., 1974, J. Med. Chem., 17, 8, 824–827.

[20] Crowe, A.J., 1989, Met.-Based Drugs, 1, 103–149.



DOI: https://doi.org/10.22146/ijc.21359

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