FORMULATION AND IN VITRO STUDY OF PROPRANOLOL HYDROCHLORIDE CONTROLLED RELEASE FROM CARBOXYMETHYL CHITOSAN-BASED MATRIX TABLETS

https://doi.org/10.22146/ijc.21283

Hernawan Hernawan(1*), Septi Nurhayati(2), Khoirun Nisa(3), A.W. Indrianingsih(4), Cici Darsih(5), Muhammad Kismurtono(6)

(1) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(2) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(3) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(4) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(5) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(6) Technical Implementation Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences, Jl. Yogya-Wonosari km 32, Gading, Playen, Gunungkidul, Yogyakarta 55861
(*) Corresponding Author

Abstract


Formulation and in vitro study of propranolol hydrochloride controlled release from carboxymethyl chitosan-based matrix tablets have been conducted. Formulations with various concentrations of carboxymethyl chitosan 2% (F1), 4% (F2), 6% (F3) were done by wet granulation method. Compatibility test was conducted by XRD and FTIR spectroscopy to determine interaction between propranolol hydrochloride and polymer excipients. Dissolution profiles was obtained through in vitro tests release using simulated gastric fluid (without enzymes, pH 1.2) for the first 2 h and followed by simulated intestinal fluid (phosphate buffer solution without enzyme, pH 7.2) for 2 h remaining. The dissolution profile of each formulation was fitted with five kinetics modeling of drug release (zero order, first order, Higuchi, Peppas-Korsmeyer, and Hixson-Crowell). The compatibility test results showed that formulation caused physical interactions between propranolol hydrochloride and polymer excipient but doesn't make crystallinity nature of propranolol hydrochloride disturbed even after formulation. Dissolution profiles of each formulation showed that controlled release of propranolol hydrochloride from the tablet followed Peppas-Korsmeyer model. It is concluded that carboxymethyl chitosan in appropriate proportions is suitable for formulating propranolol hydrochloride controlled release tablets which exhibit Peppas-Korsmeyer release kinetics.

Keywords


carboxymethyl chitosan; matrix tablets; propranolol hydrochloride; controlled release; Peppas-Korsmeyer

Full Text:

Full Text PDF


References

[1] Sahoo, J., Murthy, P.N., Biswal, S., Sahoo, S.K., and Mahapatra, A.K., 2008, AAPS PharmSciTech. 9, 2, 577–582.

[2] Martindale W.H., 1993, The Extra Pharmacopeia, 30th ed., Pharmaceutical, London, 1783.

[3] Korolkovas, A., 1988, Essentials of Medicinal Chemistry, 2nd ed., Wiley, New York, 435.

[4] Patel Monali, D., and Gevariya, H.B., 2012, World J. Pharm. Res., 1, 1, 120–127.

[5] Patel, R., Patel, H., and Patel, G., 2010, Webmed Central Pharm. Sci., 1, 10, 1–14.

[6] Pandey, S., Devmurari, V., Paridhi, S., and Mahalaxmi, R., 2010, Der Pharmacia Lettre, 2, 1, 75–86.

[7] Patra, C.N., Kumar, A.B., Pandit, K.H., Singh, S.P., and Devi, M.V., 2007, Acta Pharm., 57, 479–489.

[8] Sanghavi N.M., Sarawade V.B., Kamath P.R., and Bijilani C.P., 1998, Indian Drugs, 26, 8, 404–407.

[9] Chaturdevi, K., Umadevi, S., and Vaghani, S., 2010, Sci. Pharm., 78, 4, 927–939.

[10] Javadzadeh, Y., Musaalrezaei, L., and Nokhodchi, A., 2008, Int. J. Pharm., 362, 1-2, 102–108.

[11] Velasco-De-Paola, M.V.R., Santoro, M.I.R.M., and Gai, M.N., 1999, Drug Dev. Ind. Pharm., 25, 4, 535–541.

[12] Mohammadi-Samani, S., Adrangui, M., Siahi-Shadbad, M.R., and Nokhodchi, A., 2000, Drug Dev. Ind. Pharm., 26, 1, 91–94.

[13] Deshpande, K.B., and Ganesh, N.S., 2011, Int. J. Res. Pharm. Biomed. Sci., 2, 2, 529–534.

[14] Huang, Y-B., Tsai, Y-H., Yang, W-C., Chang, J-S, Wu, P-C., and Takayama, K., 2004, Eur. J. Pharm. Biopharm., 58, 3, 607–614.

[15] Zhang, L., Guo, J., Peng, X., and Jin, Y., 2004, J. Appl. Polym. Sci., 92, 2, 878–882.

[16] Chen, X-G., and Park, H-J., 2003, Carbohydr. Polym., 53, 4, 355–359.

[17] Bartolomei, M., Bertocchi, P., Ramusino, M.C., Santucci, N., and Valvo, L., 1999, J. Pharm. Biomed. Anal., 21, 2, 299–309.

[18] Sahoo, S.K., Mallick, A.A., Barik, B.B., and Senapati, P.Ch., 2005, Trop. J. Pharm. Res., 4, 1, 369–375.

[19] Anonymous, 1995, Farmakope Indonesia, 4th ed., Ministry of Health Republic of Indonesia, Jakarta.

[20] Lieberman, H.A., Lachman, L., and Kanig, J.L. (Eds), The Theory and Practice of Industrial Pharmacy, 2nd ed., Lea and Febiger, Philadelphia 321–340.

[21] Pratiwi, M., and Hadisoewignyo, L., 2010, Indo. J. Pharm., 21, 4, 285–295.



DOI: https://doi.org/10.22146/ijc.21283

Article Metrics

Abstract views : 2695 | views : 4131


Copyright (c) 2013 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.