A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

https://doi.org/10.22146/ijc.21279

Anggia Murni(1), Novriyandi Hanif(2*), Junichi Tanaka(3)

(1) Biopharmaca Research Center, Bogor Agricultural University, Kampus IPB Taman Kencana, Jl. Taman Kencana No. 3, Bogor 16128
(2) Department of Chemistry, Faculty of Mathematic and Natural Sciences, Bogor Agricultural University, Jl. Agatis Wing 2 Level 4, Bogor 16144
(3) Department of Chemistry, Biology and Marine Science, University of the Ryukyus Nishihara, Okinawa 903-0213
(*) Corresponding Author

Abstract


One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

Keywords


Anthelia sp.; soft coral; dolabellane; NBT-T2; cytotoxicity; marine

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DOI: https://doi.org/10.22146/ijc.21279

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