Synthesis and Characterization of Chitosan- Alginate for Controlled Release of Isoniazid Drug

https://doi.org/10.22146/ijc.21218

Sari Edi Cahyaningrum(1*), Nuniek Herdyastuti(2), Nur Qomariah(3)

(1) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(3) Department of Biology, Faculty of Mathematics and Natural Sciences, Surabaya State University, Jl. Ketintang Surabaya 60231
(*) Corresponding Author

Abstract


The aim of this research was to synthesize and characterize chitosan-calcium alginate as matrix isoniazid encapsulation to produce controlled release isoniazid drug. The microparticles were evaluated for surface morphology, functional groups, size particles, drug content and swelling index. The drug release kinetic was investigated at gastric and intestinal artificial pH. The results showed that isoniazid-calcium alginate-chitosan has majority particle diameter of 1001-1500 nm. The release mechanism of isoniazid was through combination of erosion and diffusion.

Keywords


chitosan alginate; controlled release; isoniazid

Full Text:

Full Text Pdf


References

[1] Mohanty, D.P., Palve, Y.P., Sahoo, D., and Nayak, P.L., 2012, Int. J. Pharm. Res. Allied. Sci., 1(4), 52–62.

[2] Sahoo, D., Sahoo, S., Mohanty, D.P., Sasmal, S., and Nayak, P.L., 2009, Des. Monomers Polym., 12(5), 377–404.

[3] Malesu, V.K., Sahoo, D., and Nayak, P.L., 2011, Int. J. Appl. Biol. Pharm. Technol., 2(3), 402–411.

[4] Bhise, S.B., More, A.B., and Malayandi, R., 2010, Sci. Pharm., 78(2), 291–302.

[5] Tapas, P., Paul, S, and Biswanath, S., 2010, Int. J. Pharm. Prof., 8(1), 90–98.

[6] Grenha, A., Seijo, B., and López C.R., 2005, Eur. J. Pharm. Sci., 25(4-5), 427–437.

[7] Kelner, A., and Schacht, E.H., 2005, J. Controlled Release, 101(1-3), 13–20.

[8] Sahoo, S., Sasmal, A., Nanda, R., Phani, A.R., and Nayak, P.L., 2010, Carbohydr. Polym., 79(1), 106–113.

[9] Umakanthareddy, A., Sreeramulu, J., and Punna, S., 2012, Res. J. Pharm. Biol Chem. Sci., 3(2), 725–731.

[10] Raghuvir, S., Kumar, S.S., Nagpal, K., and Saxena, N., 2010, Int. J. Pharm. Prof., 8(1), 90–98.

[11] Mahkam, M., 2009, Nat. Sci., 7(8), 1–7.

[12] Mahkam, M., 2009, J. Drug Targeting, 17(1), 29–36.

[13] Sabitha, P., Ratna, J.V., and Reddy, R., 2010, Int. J. ChemTech Res., 2(1), 88–98.

[14] Trivedi, P., Verma, A.M.L., and Garud, N., 2008, Asian J. Pharm., 2(2), 110–115.

[15] Gupta, K.C., and Jabrail, F.H., 2007, Carbohydr. Res., 342(15), 2244–2252.

[16] Sugita, P., and Lestari, S.I., 2006, J. Nature., 9(1), 32–39.

[17] Rajesh, P., and Khuller, G.K., 2005, Indian J. Novel Drug Delivery, 3(1), 57–65.

[18] Rafeeq, M.P.E., Junise, V., Saraswathi, R., Krishnan, P.N, and Dilip, C., 2010, Res. J. Pharm. Biol. Chem. Sci., 1(4), 383–390.

[19] Sharma, A., Agrawal, D., Khinchi, M.P., Sharma, N., and Gupta, M.P., 2013, Asian J. Pharm. Res. Dev., 1(2), 133–142.

[20] Silva, C.M., Riberio, A.J., Figueiredo, M., Ferreira, D., and Veiga, F., 2006, AAPS J., 7(4), E903–E912.

[21] Takahashi, T., Takayama, K., Machida, Y., and Nagai, T., 1990, Int. J. Pharm., 61(1), 35–41.

[22] Chowdary, K.P.R., Sambasiva, R.K.S., and Koteswara, R.N., 2006, Int. J. Chem. Sci., 4(1), 23–30.

[23] Kundawala, A.J., Patel, V.A., Patel, H.V., and Choundhary, D., 2012, Indian J. Novel Drug Delivery, 4(1), 57–65.



DOI: https://doi.org/10.22146/ijc.21218

Article Metrics

Abstract views : 3277 | views : 3723


Copyright (c) 2015 Indonesian Journal of Chemistry

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

 

Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.

Web Analytics View The Statistics of Indones. J. Chem.