Characterization of Butanediol-Alginate Ester as Candidate of Hemodialysis Membrane

https://doi.org/10.22146/ijc.21208

Choirul Amri(1*), Mudasir Mudasir(2), Dwi Siswanta(3), Roto Roto(4)

(1) Department of Environmental Health, Poltekkes Kermenkes Yogyakarta, Jl. Tatabumi No. 3 Banyuraden, Yogyakarta 55293
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281
(3) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara PO BOX BLS 21 Yogyakarta 55281
(*) Corresponding Author

Abstract


An ester of butanediol-alginate has been studied as a possible hemodialysis membrane. With 1,4-butanediol molar ratio of 0.1, 0.5, and 1.0, it showed that the membrane mechanical properties, stability, protein adsorption, platelet adhesion and performance for urea and creatinine clearance are better than that of unmodified alginate. The increase in 1,4-butanediol molar ratio causes hemodialysis ratio to improve, and causes protein adsorption and platelet adhesion at the membrane surface to decrease. In the case of protein adsorption and platelet adhesion, the membrane with the molar ratio of 1.0 has better hemocompatibility properties. In the hemodialysis test for 4 h, using 2.742 mg cm-2 h-1 of urea and 0.058 mg cm-2 h-1 of creatinine flux, this membrane showed that 48.5% of urea and 44.2% of creatinine were cleaned.

Keywords


butanediol-alginate ester; hemodialysis membrane; hemocompatibility

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DOI: https://doi.org/10.22146/ijc.21208

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