Pajanan toluen udara dan kejadian neuropati saraf tepi di percetakan offset

https://doi.org/10.22146/bkm.8254

Fadhila Pratamasari(1), Ismail Setyopranoto(2), Soebijanto Soebijanto(3*)

(1) Departemen Perilaku Kesehatan, Lingkungan dan Kedokteran Sosial Fakultas Kedokteran Universitas Gadjah Mada
(2) Departemen Neurologi Fakultas Kedokteran Universitas Gadjah Mada
(3) Departemen Anatomi Fakultas Kedokteran Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Air toluene exposure and peripheral neuropathy cases in offset printing

Purpose

The purpose of this paper was to determine the relationship between toluene exposure in the air at each workstation in offset printing with the incidence of peripheral neuropathy.

Methods

A cross-sectional study was conducted involving total sampling of the offset printing workers who met the criteria.

Results

The study found that there was no correlation between toluene exposure in the air with the incidence of peripheral neuropathy in offset printing workers in Sleman. Based on the ENMG test, there were only 21.42% workers diagnosed with peripheral neuropathy from 14 workers diagnosed with neuropathy; and it can be ascertained that these were not caused by toluene exposure in the air.

Conclusion

There was no correlation between toluene exposure in the air in offset printing with peripheral neuropathy for this study. Weight, length of work, and education were the factors of toluene exposure found in this study. Workers need to pay attention to the limits of the length of exposure.


Keywords


toluene exposure; peripheral neuropathy; offset printing



References

  1. Von Burg, R. Toxicology update: toluene. Jour f Appl Toxicology. 1993:13: 441–446.
  2. Bauer, B. Miljø og arbejdsmiljø i den grafiske branche. Bind 1. Ydre miljø. Miljøprojekt No. 212. Miljøstyrelsen. 1993.
  3. Svendsen, K, Rognes, KS. Exposure to organic solvents in the offset printing industry in Norway. Ann. Occup. Hyg.; 2000:44(2):119-124.
  4. Glockle, AH, Cuno, E, Hensel, T, Schultz, HJ, Sandstede, R.P. Feldstudie Toluol in Tiefdruckerien. Wiesbaden: Berufsgenossenschaft Druck und Papierverarbeitung. 1996.
  5. American Conference of Industrial Hygienists. Threshold limit values for chemical substances and physical agents and biological exposure indices 2000. Cincinnati, OH: American Conference of Governmental Industrial Hygienists. 2000.
  6. Pyor, GT. A toluene-induced motor syndrome in rats resembling that seen in some human solvent abusers. Neurotoxicology and teratology; 1991:13(4):387-400.
  7. Kang, D-M, & Kim, I. Compensation for occupational neurological and mental disorders. J Korean Med Sci, 2014:29 (Suppl):S59-S65.
  8. Stubblefield MD, Burstein HJ, Burton AW, Custodio CM, Deng GE, Ho M, Von Roenn, JH. NCCN task force report: Management of neuropathy in cancer. Journal of the National Comprehensive Cancer Network. 2009;7:S1–S26.
  9. Kutlu, G, Gomceli, YB, Sonmez, T, Inan, LE. Peripheral neuropathy and visual evoked potential changes in workers exposed to n-hexane. J of Clin Nuroscience, 2009:16 (10):1296-9.
  10. Ghanei, E, Homayooni, M, Nasrollahi, A. Rhabdomyolysis and thinner intoxication. Medical Journal of the Islamic Republic of Iran; 2007:21(3):162-166
  11. Bauer, B. Miljø og arbejdsmiljø i den grafiske branche. Bind 1. Ydre miljø. Miljøprojekt No. 212. Miljøstyrelsen. 1993.
  12. Carstensen, M. Biochemicals for the printing industry. Minneapolis, MN: The Institute for Local Self-Reliance. 1997.
  13. Svendsen, K, Rognes, K.S. Exposure to organic solvents in the offset printing industry in Norway. Ann. Occup. Hyg.; 2000: 44(2):119-124.
  14. Reza J, Salazar G, Trejo A. Evaluation of composition and evaporation behavior of commercial thinner samples expended in Mexico City. Rev Int Contam Ambient. 1997;13:87–95.
  15. Martinez-Alfaro, M, Alcarazz-Contreras, Y, Cárabez-Trejo, A, Leo-Amador, GE. Oxidative stress effects of thinner inhalation. Indian J Occup Environ Med. 2011:15(3):87-92.
  16. Ash, M. Handbook of fillers, extenders, and diluents (2nd Ed.). NY: Synapse information resources Inc. 2011.
  17. Pratamasari, F, Soebijanto, Setyopranoto, I. Kejadian neuropati saraf tepi pada pekerja percetakan ofset yang terpajan toluen [Tesis]. Yogyakarta: Universitas Gadjah Mada. 2015.
  18. Tyle, H, Larsen, HS, Andersen, LK, Brandt-Lassen, R. European Union Risk Assessment Report: toluene. Luxembourg: Office for Official Publications of the European Communities. 2003.
  19. Mørck, HI, Winkel, P, Gyntelberg, F. Health effects of toluene exposure. Dan. Med. Bull.; 1988: 35:196-200.
  20. Lee, YL, Pai, MC, Chen, J,H, Guo, YL. Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occupational Medicine, 2003:53:479–482
  21. Sclesi, R, Candura, SM. Occupational toxic neuropathies: morphology in peripheral nerve biopsies. G Ital Med Lav Ergon., 2012: 34(4):410-419.
  22. Kote, GSS, Bhat, AN, Thajuddeen, K, Ismail, MH, Gupta, A. Peripheral insensate neuropathy-is height a risk factor? J Clin Diagn Res.,2013: 7(2):296-301
  23. Fauci, B, Kasper, LH, Jameson, L. Harrison’s Principles of Internal Medicine 17th Chapter 379: Peripheral neuropathy. New York: McGraw Hill; 2008:pp. 2651–66.
  24. Von Euler, M, Pham, TM, Hillefors, M, Bjelke, B, Henriksson, B, von Euler, G. Inhalation of low concentrations of toluene induces persistent effects on a learning retention task, beam-walk performance, and cerebrocortical size in the rat. Exp Neurol, 2000:163: 1–8.
  25. Dick, F, Sample, S, Chen, R, Seaton, A. Neurological deficits in solvent‐exposed painters: a syndrome including impaired colour vision, cognitive defects, tremor and loss of vibration sensation. Q J Med., 2000:93:655-661.
  26. Keputusan Menteri Tenaga Kerja Republik Indonesia, Nomor Kep. 187/Men/1997, Tahun 1997, tentang Pengendalian Bahan Kimia Berbahaya di Tempat Kerja.
  27. Konuk, Effects of α-lipoic acid on DNA damage, protein oxidation, lipid peroxidation, and some biochemical parameters in sub chronic thinner addicted rats. Turk J Biology, 2012:36:702-710.
  28. Mold, JW, Vesely, SK, Keyl, BA, Schenk, JB, Roberts, M. The Prevalence, Predictors, and Consequences of Peripheral Sensory Neuropathy in Older Patients. J Am Board Fam Pract., 2004:17:309–18.



DOI: https://doi.org/10.22146/bkm.8254

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