Faktor yang berhubungan dengan non-konversi BTA positif pada pengobatan tuberkulosis paru di kota Semarang

https://doi.org/10.22146/bkm.7674

Marizan Marizan(1*), Yodi Mahendradhata(2), Trisno Agung Wibowo(3)

(1) Dinas Kesehatan Kabupaten Tanggamus
(2) Departemen Kebijakan dan Manajemen Kesehatan Fakultas Kedokteran Universitas Gadjah Mada
(3) Balai Laboratorium Kesehatan Yogyakarta
(*) Corresponding Author

Abstract


Factors related to non-conversion smear positive among patients with pulmonary tuberculosis in the city of Semarang

Purpose

The purpose of this study was to identify factors related to non-conversion of smear positive in treatment of new tuberculosis cases.

Methods

This study used a case control design and sampling by proportional random sampling technique. Samples were patients with smear grade positive pulmonary tuberculosis who were new cases of intensive phase of treatment and have repeated sputum examination. The numbers of samples in this research were 128 sample cases and 128 controls.

Results

The factors associated with the conversion of smear positive pulmonary tuberculosis treatment of new cases were age, sex, drug side effects, comorbidities and gradation smear results. The three variables that proved to jointly influence the incidence of smear positive conversion in the treatment of new cases of pulmonary tuberculosis were sputum smear results gradation, comorbidities and gender.

Conclusion

It is necessary to design an appropriate drug taking supervisor for patients with positive smear positive results with +2 and +3 gradations and patients with comorbidities (HIV, hepatitis, diabetes mellitus).


Keywords


non-conversion; smear positive; pulmonary tuberculosis



References

  1. Kementerian Kesehatan. Profil Kesehatan Indonesia tahun 2013, Jakarta. 2014.
  2. World Health Organization. Global Tuberculosis Report 2014.
  3. Mota PC, Carvalho A, Valente I, Braga R, Duarte R. Predictors of delayed sputum smear and culture conversion among a Portuguese population with pulmonary tuberculosis. Revista Portuguesa de Pneumologia (English Edition). 2012 Mar 1;18(2):72-9.
  4. Babalık A, Kızıltaş Ş, Arda H. Factors affecting smear conversion in tuberculosis management. Medicine Science. 2012;1(4).
  5. Reis-Santos B, Gomes T, Locatelli R, de Oliveira ER, Sanchez MN, Horta BL, Riley LW, Maciel EL. Treatment outcomes in tuberculosis patients with diabetes: a polytomous analysis using Brazilian surveillance system. PLoS One. 2014 Jul 8;9(7):e100082.
  6. Kementerian Kesehatan. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis, Jakarta. 2013.
  7. Nwokeukwu HI, Awujo DN, Emma-Ukeagbu U. Association of sputum conversion and outcome with initial smear grading among new smear positive Tuberculosis patients in a Tertiary Health Facility, South East Zone, Nigeria. Journal of Dental and Medical Sciences. 2013;4(6):2279-0853.
  8. Pefura-Yone EW, Kengne AP, Kuaban C. Non-conversion of sputum culture among patients with smear positive pulmonary tuberculosis in Cameroon: a prospective cohort study. BMC infectious diseases. 2014 Dec;14(1):138.
  9. Amaliah R. Faktor-faktor yang berhubungan dengan kegagalan konversi penderita TB Paru BTA Positif pengobatan fase intensif di Kabupaten Bekasi tahun 2010. Tesis, UI. 2010.
  10. Mi F, Tan S, Liang L, Harries AD, Hinderaker SG, Lin Y, Yue W, Chen X, Liang B, Gong F, Du J. Diabetes mellitus and tuberculosis: pattern of tuberculosis, two‐month smear conversion and treatment outcomes in Guangzhou, China. Tropical Medicine & International Health. 2013 Nov 1;18(11):1379-85.
  11. Viswanathan V, Vigneswari A, Selvan K, Satyavani K, Rajeswari R, Kapur A. Effect of diabetes on treatment outcome of smear-positive pulmonary tuberculosis—a report from South India. Journal of Diabetes and its Complications. 2014 Mar 1;28(2):162-5.
  12. Faurholt‐Jepsen D, Range N, PrayGod G, Jeremiah K, Faurholt‐Jepsen M, Aabye MG, Changalucha J, Christensen DL, Grewal H, Martinussen T, Krarup H. Diabetes is a strong predictor of mortality during tuberculosis treatment: a prospective cohort study among tuberculosis patients from Mwanza, Tanzania. Tropical Medicine & International Health. 2013 Jul 1;18(7):822-9.
  13. Jayakody W, Harries AD, Malhotra S, De Alwis S, Samaraweera S, Pallewatta N. Characteristics and outcomes of tuberculosis patients who fail to smear convert at two months in Sri Lanka. Public Health Action. 2013 Mar 21;3(1):26-30.
  14. Departemen Kesehatan. Pedoman Nasional Penanggulangan Tuberkulosis, Jakarta. 2007.
  15. Rahedi Ong'ang'o J, Mwachari C, Kipruto H, Karanja S. The effects on tuberculosis treatment adherence from utilising community health workers: a comparison of selected rural and urban settings in Kenya. PloS one. 2014 Feb 18;9(2):e88937.
  16. Shariff NM, Safian N. Diabetes mellitus and its influence on sputum smear positivity at the 2nd month of treatment among pulmonary tuberculosis patients in Kuala Lumpur, Malaysia: A case control study. International journal of mycobacteriology. 2015 Dec 1;4(4):323-9.



DOI: https://doi.org/10.22146/bkm.7674

Article Metrics

Abstract views : 1928 | views : 2421

Refbacks

  • There are currently no refbacks.




Copyright (c) 2016 Berita Kedokteran Masyarakat

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Berita Kedokteran Masyarakat ISSN 0215-1936 (PRINT), ISSN: 2614-8412 (ONLINE).

Indexed by:


Web
Analytics Visitor Counter