Faktor risiko kegagalan pengobatan ulang pasien tuberkulosis di Yogyakarta

Suharna Suharna; Ning Rintiswati

doi:10.22146/bkm.18137

Faktor risiko kegagalan pengobatan ulang pasien tuberkulosis di Yogyakarta

https://doi.org/10.22146/bkm.18137

Suharna Suharna^(1*), Ning Rintiswati⁽²⁾

(1) Dinas Kesehatan Provinsi Daerah Istimewa Yogyakarta
(2) Pusat Kedokteran Tropis Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Risk factors of unsuccess retreatment among tuberculosis patients in Yogyakarta

Purpose

The purpose of this study was to identify risk factors related to unsuccessful retreatment of tuberculosis cases in Yogyakarta.

Methods

A case-control study was conducted at the health offices of five districts from the tuberculosis registry (TB 03 and TB 01) since 2008-2014. Case group criterion was defined as unsuccessful retreatment of tuberculosis patients, whereas the control group consisted of successful retreatment of tuberculosis patients (cure or complete treatment). A total of 142 cases and 142 controls were analysed with univariate, bivariate, and multivariate analyses. Chi-square tests were conducted with p<0.05 and odds ratio (OR) at confidence interval 95%.

Results

Bivariate analysis showed that regular taking of a drug, conversion of acid-fast bacilli, and type of health services were statistically related to unsuccessful retreatment tuberculosis. Logistic regression showed that regular taking of a drug (p=0.000; OR=29.52; 95%CI=10.97-79.4) was the strongest risk factor related to unsuccessful retreatment of tuberculosis.

Conclusion

The strongest risk factor was regularly taking of a drug. District health offices need to conduct a tracking system of patients who do not take medication on schedule, ensuring regular tuberculosis medication, correct medication, and sputum examination of late-stage intensive tuberculosis patients.

Keywords

tuberculosis; unsuccessful retreatment; risk factor

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References

World Health Organization. Global Tuberculosis Report 2014. Geneva, Switzerland; 2014.
Kementerian Kesehatan. Pedoman Nasional Penanggulangan Tuberkulosis. Jakarta; 2011.
World Health Organization. Tuberculosis Control in the SEARO 2012. India; 2012.
Dinas Kesehatan. Laporan Seksi Pengendalian Penyakit. Yogyakarta; 2014.
Chakaya JM, Kibuga D, Githui WA, Mansoer JR, Gakiria G, Kwamanga D, Maende J. Tuberculosis re-treatment outcomes within the public service in Nairobi, Kenya. East African medical journal. 2002;79(1):11-5.
Jones-López, E.C., Ayakaka, I., Levin, J., Reilly, N., Mumbowa, F., Dryden-Peterson, S., Nyakoojo, G., Fennelly, K., Temple, B., Nakubulwa, S. and Joloba, M.L., 2011. Effectiveness of the standard WHOrecommended retreatment regimen (category II)for tuberculosis in Kampala, Uganda: a prospective cohort study. PLoS medicine, 8(3), p.e1000427.
Bhagat V, Gattani P. The Southeast Asian journal of tropical medicine and public health. Southeast Asian J Trop Med Public Health. SEAMEO Central Coordinating Board for Tropical Medicine and Public Health; 2010;41(5):1153–63.
Picon PD, Rizzon CF, Bassanesi SL, Silva LC, Giustina MD. Retreatment of tuberculosis patients in the city of Porto Alegre, Brazil: outcomes. Jornal Brasileiro de Pneumologia. 2011 Aug;37(4):504-11.
Takarinda KC, Harries AD, Srinath S, Mutasa-Apollo T, Sandy C, Mugurungi O. Treatment outcomes of adult patients with recurrent tuberculosis in relation to HIV status in Zimbabwe: a retrospective record review. BMC Public Health. 2012 Dec;12(1):124.
Dooley KE, Lahlou O, Knudsen J, Elmessaoudi MD, Cherkaoui I, El Aouad R. Risk factors for tuberculosis treatment failure, default, or relapse and outcomes of retreatment in Morocco. BMC public health. 2011 Dec;11(1):140.
Departemen Kesehatan. Pedoman Nasional Pengendalian Tuberkulosis. Jakarta; 2014.
Niven N. Psikologi Kesehatan: Pengantar Untuk Perawat & Profesional Kesehatan Lain. Jakarta: EGC; 2012.
Akhtar M, Bretzel G, Boulahbal F, Dawson D, Fattorini L, Feldmann K, Frieden T, Havelková M, de Kantor IN, Kim SJ, Küchler R. Technical guide: sputum examination for tuberculosis by direct microscopy in lowincome countries. Paris, France: International Union Against Tuberculosis and Lung Disease. 2000.
Rajpal S, Dhingra VK, Aggarwal JK. Sputum grading as predictor of treatment outcome in pulmonary tuberculosis. Indian Journal of Tuberculosis. 2002;49(3):139-42.
Gopi PG, Chandrasekaran V, Subramani R, Santha T. Association of conversion & cure with initial smear grading among new smear positive pulmonary tuberculosis patients treated with Category I regimen. Indian Journal of Medical Research. 2006 Jun 1;123(6):807.
Tiwari S, Kumar A, Kapoor SK. Relationship between sputum smear grading and smear conversion rate and treatment outcome in the patients of pulmonary tuberculosis undergoing dots-a prospective cohort study. Indian Journal Tuberculosis. 2012 Jul;59(3):135–40.
Prasanna KT, Arun BJ, Uma MK. A prospective study of sputum conversion rate and cure rate in smear positive retreatment patients under RNTCP in rural population. Journal of Evolution of Medical and Dental Sciences. 2015 Jun 8;4(46):7900-19.
Mukherjee A, Sarkar A, Saha I, Biswas B, Bhattacharyya P, Ps B. Outcomes of different subgroups of smear- positive retreatment patients under RNTCP in rural West Bengal, India Outcomes of different subgroups of smear-positive retreatment patients under RNTCP in rural West Bengal, India. Rural Remote Health. 2009;9.
Kementerian Kesehatan. Keputusan Menteri Kesehatan No. 75 tahun 2014 tentang Puskesmas. Jakarta; 2014.
Kementerian hukum dan hak asasi manusia R. Undang-undang Republik Indonesia No.44 tahun 2009 tentang Rumah Sakit. Jakarta; 2009.
Kementerian Kesehatan. Pedoman Nasional Pelayanan Kedokteran Tata Laksana Tuberkulosis. Jakarta; 2013.