The Effect of Bilateral Orchiectomy on Total Prostate Specific Antigen (TPSA) Levels in Prostate Adenocarcinoma Patients

WIKAN KURNIAWAN Sp.U

doi:10.22146/ahj.v6i1.98565

The Effect of Bilateral Orchiectomy on Total Prostate Specific Antigen (TPSA) Levels in Prostate Adenocarcinoma Patients

https://doi.org/10.22146/ahj.v6i1.98565

WIKAN KURNIAWAN Sp.U^(1*)

(1) RSA UGM
(*) Corresponding Author

Abstract

Abstract

Background: Hormonal therapy is one treatment option for prostate cancer. There are two main categories of hormone therapy: surgical therapy and non-surgical therapy. Orchiectomy is the surgical method of hormone therapy; medication supplementation is the non-surgical method. Many kinds of indicators are used to track the advancement of patients with prostate cancer receiving hormone therapy. tPSA levels are one of the markers that are regularly evaluated.

Methods: In this retrospective study, PSA levels in patients with prostate adenocarcinoma cancer were evaluated before and after bilateral orchiectomy. Use the search terms "prostate cancer" and "orchiectomy" to find research subject data in the UGM Academic Hospital's medical records installation between 2020 and 2023. The study's findings will be shown in a graphic and statistical analysis while protecting the subjects' anonymity.

Results: Most of the participants (n=18, 60.0%) have pre-orchiectomy tPSA level of more than 30 ng/mL, while only almost a quarter (n=7, 23.3%) of participants have post-orchiectomy tPSA level of more than 30 ng/mL. The two research groups (p<0.0001) before and after the orchiectomy procedure, significantly differ between the two research groups based on Wilcoxon paired sample test analysis.

Conclusion: TPSA levels are considerably decreased by bilateral orchiectomy.

Keywords

tPSA; orchiectomy, adenocarsinoma; prostate

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References

Atta, M. A., Elabbady, A., Sameh, W., Sharafeldeen, M., & Elsaqa, M. (2020). Is there still a role for bilateral orchidectomy in androgen-deprivation therapy for metastatic prostate cancer? Arab Journal of Urology, 18(1), 9–13. https://doi.org/10.1080/2090598X.2019.1690270 Charig, C. R., & Rundle, J. S. (1989). Flushing long-term side effect of orchiectomy in treatment of prostatic carcinoma. Urology, 33(3), 175–178. https://doi.org/10.1016/0090-4295(89)90385-3 David, M. K., & Leslie, S. W. (2022). Prostate Specific Antigen—StatPearls—NCBI Bookshelf. In StatPearls (pp. 1–40). StatPearls Publishing LLC. Desai, K., McManus, J. M., & Sharifi, N. (2021). Hormonal therapy for prostate cancer. Endocrine Reviews, 42(3), 354–373. https://doi.org/10.1210/endrev/bnab002 Kan, H.-C., Hou, C.-P., Lin, Y.-H., Tsui, K.-H., Chang, P.-L., & Chen, C.-L. (2017). Prognosis of prostate cancer with initial prostate-specific antigen >1,000 ng/mL at diagnosis. OncoTargets and Therapy, 10, 2943–2949. https://doi.org/10.2147/OTT.S134411 Leibovici, D., Spiess, P. E., Agarwal, P. K., Tu, S. M., Pettaway, C. A., Hitzhusen, K., Millikan, R. E., & Pisters, L. L. (2007). Prostate cancer progression in the presence of undetectable or low serum prostate-specific antigen level. Cancer, 109(2), 198–204. https://doi.org/10.1002/cncr.22372 N. Motet, P. Cornford, R.C.N. van den Berg, E. Briers, D. E. et all. (2023). EAU Guidelines. Prostate cancer. European Association of Urology, 1–234. Namiki, M., Ueno, S., & Kitagawa, Y. (2012). Role of hormonal therapy for prostate cancer: Perspective from Japanese experiences. Translational Andrology and Urology, 1(3), 160–172. https://doi.org/10.3978/j.issn.2223-4683.2012.07.03 Sarin Itty, R. H. G. (2020). How do we define “castration” in men on androgen deprivation therapy? Asian Journal of Andrology, 21(July), 1–4. https://doi.org/10.4103/aja.aja von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P., & STROBE Initiative. (2008). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Journal of Clinical Epidemiology, 61(4), 344–349. https://doi.org/10.1016/j.jclinepi.2007.11.008

DOI: https://doi.org/10.22146/ahj.v6i1.98565