ANTIINFLAMMATION EFFECT OF SKUNKVINE (Paederia scandens) EXTRACT IN WISTAR RAT

https://doi.org/10.22146/tradmedj.8374

Evy Tri Utami(1*), Rebecca Azary Kuncoro(2), Islamy Rahma Hutami(3), Finsa Tisna Sari(4), Juni Handajani(5)

(1) Faculty of Dentistry, Universitas Gadjah Mada
(2) Faculty of Dentistry, Universitas Gadjah Mada
(3) Faculty of Dentistry, Universitas Gadjah Mada
(4) Faculty of Dentistry, Universitas Gadjah Mada
(5) Faculty of Dentistry, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Inflammation is a protective action that role on defending mechanism to defeat agent causing cell injury. Glucoside of skunkvine (Paederia scandens) has anti-inflammation effect. The aim of this study was to know the anti anti-inflammatory effect of skunkvine (Paederia scandens) extract on artificial edema in Wistar rat. Thirty-five Wistar rats were divided into 7 groups, each group consisted 5 rats. In the control and treatment groups, aquadest (negative control), fenilbutazon (positive control), skunkvine extracts in dose 10mg/kgBW, 20mg/kgBW 30mg/kgBW, 40mg/kgBW, and 50mg/kgBW were administered per orally. In order to induce the edema, one hour after administration, in each group, right hind paw of the rats was injected subcutaneously with by 1% carrageenin. The volume measurement performed with one hour interval for 5 hours assessing with pletysmometer. The data were analyzed by ANOVA. The result of this study showed there was significant difference on group with skunkvine extract 20mg/kg BW to negative control and positive control. In conclusion, that the skunkvine extract 20 mg/kgBW has potency as anti-inflammation substance.


Keywords


skunkvine (Paederia scandens), anti-inflammation, edema



References

Anosike, C.A., Obidoa, O., Ezeanyika, L.U.S. dan Nwuba M.M., 2009, Anti-inflammatory and Anti-ulcerogenic Activity of The Ethanol Extract of Ginger (Zingiber officinale), African Journal of Biochemistry Research, 3(12), 379-384

Aronson, J.K, 2009, Meyler’s Side Effects of Herbal Medicines, Oxford, Elsevier, 117

Bruera, E. dan Portenoy, R.K., 2003, Cancer Pain: Assessment and Management, Cambridge, Cambridge University Press, 14

El-Moaty, H.I.A., 2010, Essential Oil and Iridoid Glycoside of Nepeta septemcrenata Erenb. Journal of Natural Products, 3,103-11

Guyton, A.C. dan Hall, J.E., 1997, Buku Ajar Fisiologi Kedokteran, Edisi 9, Jakarta, EGC, 1212

Hapsari H.D., Handajani, J. dan Tandelilin, R.T.C., 2006, Efektivitas Ekstrak Etanol Buah Mengkudu sebagai Bahan Anti Inflamasi pada Tikus Wistar, Majalah Ilmiah Kedokteran Gigi, 21(2), 60-8

Janinová, V., Petríková, M., Pereko, T., Drábiková, K. dan Nosáľ, R., 2007, Inhibition of Neutrophil Oxidative Burst with Arbutin. Effects In Vitro and in Adjuvant Arthritis. Chem. Listy, 101, s73−s310

Jorge, Parada, C.A., Ferreira, S.H. dan Tambeli, C.H., 2006, Interferential Therapy Produces Antinociception During Application in Various Models of Inflammatory Pain, Physical Therapy, 86(6), 800-8.

Kumar, V., Abbas, A.K., Fausto, N. dan Mitchell R.N., 2007, Robbins Basic Pathology, Philadelpia, Saunders Elsevier, 37-41, 53-5

Lans, C., Turner, N., Brauer, G., Lourenco, G. dan Georges, K., 2006, Ethnoveterinary Medicines Used for Horses in Trinidad and In British Columbia, Canada, Journal of Ethnobiology and Ethnomedicine, 2, 31-50

Ma, Y., Zhou, L.L., Yan, H.Y. dan Liu, M., 2009, Effects of Extracts from Paederia scandens (LOUR.) MERRILL (Rubiaceae) on MSU Crystal-Induced Rats Gouty Arthritis, The American Journal of Chinese Medicine, 37(4), 669-83

Mansjoer, S., 1997, Efek Antiradang Minyak Atsiri Temu Putih (Curcuma Zedoria Rosc.) terhadap Udem Buatan pada Tikus Putih Betina Galur Wistar, Majalah Farmasi Indonesia, 8, 35-41

McKenna, D.J., Jones, K., Hughes, K. dan Humphrey, S., 2002, Botanical Medicines: The Desk Reference for Major Herbal Supplements, 2nd ed, New York, The Haworth Herbal Press, 996

Parmar, N.S. dan Ghosh, M.N., 1980, Comparative Effects of Gossypin and Phenylbutazon on The Temporal Characteristics of Carrageenin Induced Paw Oedema and Increased Vascular Permeability in Rat, Indian Journal Pharmacy, 12(3), 203

Quang, D.N., Hashimoto, T., Tanaka, M., Dung, N.X. dan Asakawa, Y., 2002, Iridoid glucosides from roots of Vietnamese Paederia scandens, Phytochemistry, 60, 505-14

Solikin, 2007, Potensi Jenis-jenis Herba Liar di Kebun Raya Purwodadi sebagai Obat, http://fisika.brawijaya.ac.id/bss-ub/proceeding/PDF%20FILES/BSS_118_2.pdf, 4 Mei 2009

Tanu, I., Syarif, A., Estuningtyas, A., Setiawati, A., Muchtar, H.A. dan Arif, A., 2002, Farmakologi dan Terapi, Jakarta, FKUI, 216-7

Trim, A.R. dan Hill, R., 1952, The Preparation and Properties of Aucubin, Asperuloside and Some Related Glycosides, Biochemisty Journal, 50, 310-8

Tsokos, G.C., 2002, Modern Therapeutics in Rheumatic Diseases, Totowa, Humana Press, 26-7

Utami, P., 2008, Buku Pintar Tanaman Obat, Jakarta, Agromedia, 63-4.

Vogel, H.G., 2008, Drug Discovery and Evaluation: Pharmacological Assays, Berlin, Springer, 1107

Xu, Z., Shulin, P., Xin, L., Bingru, B. dan Lisheng, D., 2006, Sulfur-containing iridoid glucosides from Paederia scandens. Fitoterapia, 77(5), 374-7



DOI: https://doi.org/10.22146/tradmedj.8374

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