ANTIINFLAMMATION EFFECT OF SKUNKVINE (Paederia scandens) EXTRACT IN WISTAR RAT

https://doi.org/10.22146/tradmedj.8374

Evy Tri Utami(1*), Rebecca Azary Kuncoro(2), Islamy Rahma Hutami(3), Finsa Tisna Sari(4), Juni Handajani(5)

(1) Faculty of Dentistry, Universitas Gadjah Mada
(2) Faculty of Dentistry, Universitas Gadjah Mada
(3) Faculty of Dentistry, Universitas Gadjah Mada
(4) Faculty of Dentistry, Universitas Gadjah Mada
(5) Faculty of Dentistry, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Inflammation is a protective action that role on defending mechanism to defeat agent causing cell injury. Glucoside of skunkvine (Paederia scandens) has anti-inflammation effect. The aim of this study was to know the anti anti-inflammatory effect of skunkvine (Paederia scandens) extract on artificial edema in Wistar rat. Thirty-five Wistar rats were divided into 7 groups, each group consisted 5 rats. In the control and treatment groups, aquadest (negative control), fenilbutazon (positive control), skunkvine extracts in dose 10mg/kgBW, 20mg/kgBW 30mg/kgBW, 40mg/kgBW, and 50mg/kgBW were administered per orally. In order to induce the edema, one hour after administration, in each group, right hind paw of the rats was injected subcutaneously with by 1% carrageenin. The volume measurement performed with one hour interval for 5 hours assessing with pletysmometer. The data were analyzed by ANOVA. The result of this study showed there was significant difference on group with skunkvine extract 20mg/kg BW to negative control and positive control. In conclusion, that the skunkvine extract 20 mg/kgBW has potency as anti-inflammation substance.


Keywords


skunkvine (Paederia scandens), anti-inflammation, edema



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DOI: https://doi.org/10.22146/tradmedj.8374

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