HOMA-IR INDEX EVALUATION ON ANTIDIABETES MELLITUS EFFECT OF Andrographis paniculata (Burm. f.) Nees PURIFIED EXTRACT AND ANDROGRAPHOLIDE

https://doi.org/10.22146/tradmedj.8086

Ignatius Ryan Adriawan(1), Mohamad Andrie(2), Rina Susilowati(3), Suwidjiyo Pramono(4), Agung Endro Nugroho(5*)

(1) Faculty of Medicine, Universitas Gadjah Mada
(2) Faculty of Medicine, Tanjungpura University
(3) Faculty of Medicine, Universitas Gadjah Mada
(4) Faculty of Pharmacy, Universitas Gadjah Mada
(5) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Diabetes mellitus type 2 was induced by high fat diet and fructose. The insulin resistance and hyperinsulinemia compensatory can be measured by index homeostatic model assessment – insulin resistance (HOMA-IR). Andrographis paniculata (Burm. f.) Nees is a traditional plant can be used to treat diabetes mellitus and the main active compound of this plant is Andrographolide. The objective of this study is to evaluate the effect of purified extract of Andrographis paniculata (Burm. f.) Nees and andrographolide on HOMA-IR index of High fat diet and fructose induced Wistar Rats. This study is quasi-experimental and data analysis was using Kruskal-Wallis test. The result showed that purified extract of Andrographis paniculata and andrographolide decreased HOMA-IR index. Purified extract of Andrographis paniculata 1303,8 mg/kg decreased HOMA-IR index by 82,05 %.


Keywords


purified extract of Andrographis paniculata, Andrographolide, HOMA-IR index, High fat and fructose diet

Full Text:

PDF


References

Andrie, M. 2012. Uji Aktivitas Antidiabetes Mellitus (DM) Tipe 2 Andrografolid dan Ekstrak Terpurifikasi Herba Sambiloto (Andrographis paniculata (Burm. f.) Nees.) Melalui Peningkatan Translokasi Protein GLUT-4 pada Otot Paha Tikus Resisten Insulin. Tesis. Universitas Gadjah Mada

Bremer, A. A., Mietus-Snyder, M., Lustig, R. H. 2012. Toward a Unifying Hypothesis of Metabolic Syndrome. Pediatrics 129(3):557-570.

DeFronzo, R. A. 2004. Pathogenesis of Type 2 Diabetes Mellitus. Med Clin N Am 88:787-835

Hirata, A., Maeda, N., Hiuge, A., Hibuse, T., Fujita, K., Okada, T., Kihara, S., Funahashi, T., Shimomura, I. 2009. Blockade of Mineralocorticoid Receptor Reverses Adipocyte Dysfunction and Insulin Resistance in Obese Mice. Cardiovascular Research 84:164-172

International Diabetes Federation. 2013. Diabetes Atlas, edisi ke-6. Brussels: International Diabetes Federation

Jayakumar, T., Hsieh, C. Y., Lee, J. J., Sheu, J. R. 2013. Experimental and Clinical Pharmacology of Andrographis paniculata and Its Major Bioactive Phytoconstituent Andrographolide. Evid Based Complement Alternat Med 2013:846740

Nugroho, A. E., Andrie, M., Warditiani, N. K., Siswanto, E., Pramono, S., Lukitaningsih, E. 2012. Antidiabetic and Antihiperlipidemic Effect of Andrographis paniculata (Burm. f.) Nees and Andrographolide in High-Frucotse-Fat-Fed Rats. Indian J Pharmacol 44(3):377-381

Rasoanaivo, P., Wright, C. W., Willcox, M. L., Gilbert, B. 2011. Whole Plant Extracts versus Single Compounds for the Treatment of Malaria: Synergy and Positive Interactions. Malaria Journal 10(Suppl 1):S4.

Shulman, G. I. 2000. Cellular Mechanism of Insulin Resistance. J Clin Invest 106:171-76

Subramanian, R., Asmawi, M. Z., Sadikun, A. 2008. Effect of Andrographolide and Ethanol Extract of Andrographis paniculata on Liver Glycolytic, Gluconeogenic, and Lipogenic Enzymes in a Type 2 Diabetic Rat Model. Pharmaceutical Biology 46(10-11):772-780

Subramanian, R., Asmawi, M. Z., Sadikun, A. 2008. Effect of Ethanolic Extract of Andrographis paniculata (Burm. f.) Nees on a Combination of Fat-Fed Diet and Low Dose Streptozotocin Induced Chronic Insulin Resistance in Rats. Diabetologia Croatica 37-1

Wibudi, A. 2006. Mekanisme Kerja Sambiloto sebagai Antidiabetes. Disertasi. Institut Pertanian Bogor

Widyawati, T. 2007. Aspek Farmakologi Sambiloto (Andrographis paniculata Nees). Majalah Kedokteran Nusantara 40(3):216-222.

Zhang X. F., Tan, B. K. H. 2000. Anti-diabetic Property of Ethanolic Extract of Andrographis paniculata in Streptozotocin-Diabetic Rats. Acta Pharmacol Sin 21(12):1157-1164

Zhang, Z., Jiang, J., Yu, P., Zeng, X., Larrick, J. W., Wang, Y. 2009. Hypoglycemic and Beta Cell Protective Effects of Andrographolide Analogue for Diabetes Treatment. Journal of Translational Medicine 7:62



DOI: https://doi.org/10.22146/tradmedj.8086

Article Metrics

Abstract views : 2132 | views : 4880

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2015 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada