ANTI-INFLAMMATORY ACTIVITYY OF Piper crocatum Ruiz & Pav. LEAVES METANOLIC EXTRACT IN RATS
Atik Fitriyani(1), Lina Winarti(2*), Siti Muslichah(3), Nuri Nuri(4)
(1) Faculty of Pharmacy, University of Jember
(2) Faculty of Pharmacy, University of Jember
(3) Faculty of Pharmacy, University of Jember
(4) Faculty of Pharmacy, University of Jember
(*) Corresponding Author
Abstract
Inflammation is a natural respon for tissue damage. To reduce inflammation, people used a NSAID (Non Steroid Antiinflammatory Drugs). This agent caused many side effects. One of medicinal plant empirically used for traditional medicine is Piper Crocatum Ruiz & Pav. This plant is potential to be developed as medicine for anti-inflammatory because its contains flavonoid, saponin, tannin, and alkaloid. The aim of this study was to investigate the anti-inflammatory effect of the P.Crocatum extract using carrageenan-induced rat oedema test. For the anti-inflammatory activity measurement, five different groups were established and piper extract was administered in three different doses : 25, 50 and 100 mg/kgBW. Acetosal was used as a reference agent. It was found that reduction in the flammation was 77.58% for acetosal, 72.37% for 25 mg/kg extract, 85.60% for 50mg/kg, and 81.02% mg/kg for 100mg/kg extract. Extract of P. Crocatum at 50 mg/kg showed the strongest anti-inflammatory activity among the doses used. The results showed that P. Crocatum extract posseses promising anti-inflammatory effect.
Keywords
Full Text:
pdf (Bahasa Indonesia)References
Anonim, 2005. Hati-hati menggunakan Obat Anti Nyeri,(http://www.diskesjatim.go.id/berit a-detail.html?news_id=90) (24 Mei 2005)
Arundina, I., Laksminingsih, R., Yuliastuti, W.S. 2003. Efek Antiinflasi Catechin pada Marmut dengan Metode Pembentukan Oedema yang Diinduksi Karagenik. Jurnal Penelitian Medika Eksakta, 4 (3): 189-195
Esvandiary, J., Sekar, M.F., Wijoyo, Y. 2007. Efek analgetik dan Efek Anti Inflamasi Beta Karoten pada Mencit
Fong, H.S., Tin Wa, M., Farnsworth, N.R., 1973, Phytochemical Screening, Chicago: Department of Pharmacognosy & Pharmacology, College of Pharmacy, University of Illionis
Judd, W.S., Cambpbell, C.S., Kellog, E.A. & Donoghue, M.J. (2002): Plant Systematics:a Phylogenetic Approach, Sinauer, Sunderland, Mass
Kamienski, M., Keogh, J., 2006, Pharmacology Demystified:a Self-Teaching Guide, New York: The McGraw-Hill Companies, Inc
Khanbabaee, K. dan Ree, T. V. 2001. Tannins: Classification and Definition. Nat Prod Rep, 18: 641-649
Kurniawati, A. 2005. Uji Aktivitas Anti Inflamasi Ekstrak Metanol Graptophyllum griff pada Tikus Putih. Majalah Kedokteran Gigi Edisi Khusus Temu Ilmiah Nasional IV, 11-13 Agustus 2005: 167-170
Mycek, M.J., R.A. Harvey dan P.C. Champe. 2001. Farmakologi Ulasan Bergambar. Edisi 2. Jakarta: Widya Medika
DOI: https://doi.org/10.22146/tradmedj.8020
Article Metrics
Abstract views : 12338 | views : 66372Refbacks
- There are currently no refbacks.
Copyright (c) 2011 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada