LOZENGES FORMULATION OFTURMERIC EXTRACT (Curcuma domestica) WITH COMBINATION OF FILLER AGENTS MANITOL – AMYLUM MANIHOT

https://doi.org/10.22146/tradmedj.8010

Farida Haryanti(1), Indah Purwantini(2), T. Nanda Saifullah Sulaiman(3*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Hydroalcoholic extract of turmeric is recommended as supplement to prevent atherosclerosis, but the common dosage form in traditional practices is less practical and unacceptable. It is therefore recommended to be mad into new dosage form, lozenges. This research aims to determine the effect of filler agent manitol-amylum manihot variations to the physical characteristics of granule, tablet, and the flavor of the tablet. The optimum formula was evaluated with simplex lattice design method. The hydro extract of turmeric was made using aquadest 80OC while the alcoholic extract using ethanol 96%. Hydro alcoholic extract was made by mixing both extracts, wet granulated and formulated into five formulas with combination of manitol-amylum manihot ratio. The result showed that the combination of manitol-amylum manihot had affected the tablet hardness, solubility time and flavor acceptance. The formula with the combination manitol-amylum manihot 80% : 20% was found to be the optimum formula.

Keywords


turmeric rhizome, filler agents, simplex lattice design, lozenges



References

Alderborn, C., 2002, Tablets and Compaction, dalam Aulton, M.E., (Ed), Pharmaceutics The Science of Dosage Form Design, 2nd Ed.,413, Churchill Livingstone, Edinburgh

Anonim. 1979.Farmakope Indonesia, Edisi III. Departemen Kesehatan Republik Indonesia, Jakarta. pp.654

Anonim, 1985, Cara Pembuatan Simplisia, 4-15, Departemen Kesehatan Republik Indonesia, Jakarta

Armstrong, N. A., 2006, Mannitol, dalam Rowe, R. C., Sheskey, P. J., dan Owen, S. C., (Eds.), Handbook of Pharmaceutical Excipients, 5th Ed., 449-453, Pharmaceutical Press, London

Galichet, L. Y., 2006, Starch, dalam Rowe, R. C., Sheskey, P. J., dan Owen, S. C., (Eds.), Handbook of Pharmaceutical Excipients, 5th Ed., 725-730, Pharmaceutical Press, London

Gohel.M.C., Parikh, R.K., Brahmbhatt, B.K., dan Shah, A.R., 2007, Preparation and Assessment of Novel Coproceesed Superdisintregant Consisting of Crospovidone and Sodium Starch Glycolate: A Technical Note, AAPS PharmSciTech., 8(1), 1-13

Necel, 2009, Atherosklerosis, http://atherosklerosis.html, 3 Mei 2009.Anonim.1985.Tanaman Obat Indonesia I. Departemen Kesehatan RI, Jakarta.pp 45

Quiles, J.L., M. Dolores, M., Cesar, L., Ramirez-Tortosa, Concepcion M., Aguilera, Maurizio, Battino, Angel Gil and M. Carmen Ramirez-Tortosa, 2002, Curcuma longa Extract Supplementation Reduces Oxidative Stress and Attenuates Aortic Fatty Streak Development in Rabbits, Arterioscler.Thromb.Vasc. Biol. 2002;22;1225-1231

Rahayu, D.Y., 2004, Pengaruh Perbandingan Bahan Pengisi Manitol-Dekstrosa Terhadap Kualitas Tablet Hisap Ekstrak Rimpang Temu Mangga (Curcuma mangga Val.), Skripsi, Fakultas Farmasi Universitas Gadjah Mada Yogyakarta

Rosanske, T.W., 1990, Granulation Technology and Tablet Character in Lieberman H.A., Lachman, L., Schwartz, J.B., (Eds.), Pharmaceutical Dosage Forms Tablets, Volume II, 327-330, Marcel Dekker, New York

Stahl, E., 1985, Analisis Obat Secara Kromatografi dan Mikroskopi, diterjemahkan oleh Kosasih Padmawinata & Iwang Soediro, 3-4, Penerbit ITB, Bandung

Voigt, R., 1984, Buku Ajar Teknologi Farmasi, 167 – 168, 199 – 200, 579 -580 Gadjah Mada University Press, Yogyakarta



DOI: https://doi.org/10.22146/tradmedj.8010

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