ACTIVITIES OF YAM STARCH (Pachyrhizus erosus (L.) Urban) AS SUNSCREEN IN MOUSE AND THE EFFECT OF ITS CONCENTRATION TO VISCOSITY LEVEL

https://doi.org/10.22146/tradmedj.7754

A. Karim Zulkarnain(1*), Novi Ernawati(2), Nurul Ikka Sukardani(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Yam starch (Pachyrhizus erosus (L.) Urb.) with microparticles of size and had opaque properties could be used as an physical sunscreens. Yam starch was made in creams and lotions formulation and applied topically. This study aimed to determine the effect of yam starch concentration to the increasing of creams and lotions formulation as well as sunscreens activity in mice seen from its Sun Protecting Factor (SPF). Yam starch was obtained by the deposition method, then was done characterization and measurement of particle diameter. The formulation of creams and lotions each in 3 formulas with yam starch concentration of 15%, 20%, and 25%, further the viscosity and physical stability were observed under extreme heat and cold conditions. The observations during storage were colour, odor, homogenity, and viscosity. Sunscreen activity was determined by in vivo method using Swiss Webster female mice strains induced by 8-MOP, and then observation of its SPF value. The viscosity data  in extreme hot and cold conditions was analyzed statistically at significance level of 95%. The results showed that the more increase of  the concentration of yam starch the more  increase of viscosity, while the colour, odor, and homogenity of the formulation did not change during storage. Creams and lotions formulation with starch concentration of 15%, 20%, and 25%, had sunscreen activity in vivo in mice, with SPF value of 1.22; 1.52, and 2.38.


Keywords


yam starch, cream, lotion, stability, sunscreen



References

Anonim, 1966, Formularium Indonesia, 32, Departemen Kesehatan Republik Indonesia, Jakarta

Anonim, 2012, Ultraviolet Berisiko Penuaan Dini, http://www.resep.web.id/kesehatan/ultraviolet-berisiko-penuaan-dini.htm (diakses bulan Juli 2012)

Bennett, H., 1970, The New Cosmetic Formulary, 44, Chemical Publishing Company, New York

Brezova, V., Gabcova, S., Dvoranova, D., Stasko, A., 2005, Reactive Oxygen Spesies Produced Upon Photoexcitation of Sunscreens Containing Titanium Dioxide (an EPR Study), Journal of Photochemistry and Photobiology B: Biology, 79, 121-134

Draelos, Z. D., &Thaman, L. A., 2006, 157-159, Cosmetic Formulation of Skin Care Products, Taylor and Francis Group, New York

Dwiastuti, R.,2007, Optimasi Proses Pembuatan Krim Sunscreen Ekstrak Kering Polifenol Teh Hijau ( Camellia Sinensis L.) dengan Metode Desain Faktorial, Tesis, Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta

Green, A., William, G., and Neale, R., 1999, Does Daily Use of Sunscreen or β carotene Supplements Prevent Skin Cancer in Healthy Adults?, 354, 723-729, Lancet

Joshita, 1998, Stability Testing of Cosmetics Product, Personal Care Ingredient Asia Conference Paper, Step Exhibitions Limited, 1-9, Tumbridge Wells

Osterwalder, U., Herzog, B., 2009, European Commission Recommendation on the Efficacy of Sunscreen Products and the Claims Made Relating Thereto, 2006, Sun Protection Factors: World Wide Confusion, British Journal of Dermatology, 161, 3-24

Fitzpatrick, T.B., & Freedberg, I.M., 2008, Fitzpatrick’s Dermatology in General Medicine, 7th Ed, Volume 1, 30, McGraw-Hill Companies Inc, New York

Garoli, D., Pelizzo, M.G., Nicolossi, P., Peserico, A., Tonin, E., Alaibac, M., 2009, Effectiveness of Different Substrate Materials for In Vitro Sunscreen Test, Journal of Dermatological Science, 56, Issue 2, November 2009, 89-98

Harry, R.G., 1982, The Principle and Practice of Modern Cosmetics, 6th Ed., 306-320; 702-705, Leonard Hill Book, London

Lee, A., &Kaplan, M.D., 1992, Suntan, Sunburn, and Sun Protection, Journal of Wildernes Medicine 3, 174-175, 179

Mitsui, T., 1997, New Cosmetic Science, 32-38, 142, Elsevier Science B.V., Netherlands

Nursal, K.F., Asyarie, S., T.D, Sasanti., Imaculata, M., 2006, Formulasi dan Uji Keamanan serta Aktivitas Krim Pati Beras (Amylum oryzae) dan Pati Jagung (Amylum Maydis) sebagai Tabir Surya, Majalah Farmasi Indonesia, 3 No.2, Desember 2006

Pathak, M.A., 1982, Sunscreens: Topical and Systemic Approaches for Protection of Human Skin Against Harmful Effects of Solar Radiation,J Am Acad Dermatol, 7, 285-312 cit Lee, A., Kaplan, M.D., 1992, Suntan, Sunburn, and Sun Protection, Journal of Wildernes Medicine 3, 174-175, 179

Poskitt, E.M., Cole, T.J., Lawson, D.E., 1979, Diet, Sunlight, and 25-hydroxy-Vitamin D in Healthy Children and Adults. Brit Med,1, 221

Rieger, M.M., 2000. Harry Cosmeticology 8th edition, 20-36, 228, 247-251, Chemical Publishing Co., Inc., New York

Shaath, N. A., 1990, The Chemistry of Sunscreens, in Sunscreens : Development, Evaluation, and Regulatory Aspect, Lowe, N. J., and N. A. Shaath (Eds.), 211-232 Marcel Dekker Inc., New York

Sinko, P.J., 2006, Physical Pharmacy and Pharmaceutical Sciences, 5th Ed, 509-510, 533, 535, 537, 541-542, 561, 562-564, Lippincott William & Wilkins, Philadelphia

Stanfield, J.W., 2003, Sun Protectans: Enhancing Product Functionality in Sunscreen, in Schueller, R. Romanowski, P., (Eds), Multifunctional Cosmetics, 145, Marcell Dekker Inc., New York

Tranggono, R.I.S, F. Latifah & J. Djajadisastra (ed), 2007, Buku Pegangan Ilmu Pengetahuan Kosmetik,6-8, PT. Gramedia Pustaka Utama, Jakarta

Walters, C., Keeney, A., Wigal, C.T., Johnston, C.R., Cornelius, R.D., 1997, Spectroscopy Analysis and Modelling of Sunscreens, 99-101, J. Chem. Educ.

Willis, I., & Cylus, L., 1977, UVA Erythema in Skin: Is It a Sunburn?, J Invest Dermato. 9, 68, 128 cit Lee, A., Kaplan, M.D., 1992, Suntan, Sunburn, and Sun Protection, Journal of Wildernes Medicine 3, 174-175, 179

Wasitaatmadja, S.M., 1997, Penuntun Ilmu Kosmetik Medik, 3, 4, 11-15, 23, 117-120, Universitas Indonesia Press, Jakarta



DOI: https://doi.org/10.22146/tradmedj.7754

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