.png)
.png)
* Corresponding Author
The Potency of Alpinia galanga as Natural Antioxidant
https://doi.org/10.22146/mot.72450 Dian Ratih Laksmitawati(1*), Diah Kartika Pratami(2), Wahyu Widowati(3), Hanna Sari Widya Kusuma(4), Cahyaning Riski Wijayanti(5), Rizal Rizal(6)
(1) Faculty of Pharmacy, Pancasila University, Jakarta
(2) Faculty of Pharmacy, Pancasila University, Jakarta
(3) Faculty of Medicine, Maranatha Christian University, Bandung, West Java
(4) Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Bandung, West Java
(5) Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Bandung, West Java
(6) 1) Biomolecular and Biomedical Research Centre, Aretha Medika Utama, Bandung, West Java 2) Faculty of Engineering, University of Indonesia, Depok, West Java
(*) Corresponding Author
Abstract
An antioxidant is a chemical compound that can bind free radicals in the body. Reactive oxidative species (ROS) is a reaction that involves oxygen. ROS consists of free radicals and non-radical ones. The imbalance between ROS and antioxidants can cause oxidative stress, one of the factors contributing to the development of numerous diseases. This study aims to evaluate the possible antioxidant activity of lengkuas extract (LE), which may be employed as a medicine component to reduce ROS. The method that used in this research were total phenolic content, total flavonoid content, 2,2 diphenyl 1 picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), NO scavenging, 2,2′-Azinobis(3-Ethylbenzthiazoline-6-Sulfonate) (ABTS), and ferric reducing antioxidant power (FRAP). The result shows that the TPC of LE was 6.80 ± 0.34 (GAE) µg/mg with gallic acid standard and the TFC was 3.39 ± 0.06 µg/mg by quercetin standard. The IC50 value of LE were 121.20; 87.65; 139.94; 181.09 µg/ml by ABTS, DPPH, NO, and H2O2 assay respectively. The scavenging activity of LE was increased with a higher concentration in every method. In conclusion, Alpinia galanga has the potential as an antioxidant. Thus, it can be widely consumed or used as a mixture in medicine to reduce ROS.
Keywords
Full Text:
PDFReferences
Ahmed, F. & Iqbal, M. (2018). Antioxidant activity of Ricinus Communis. Organic & Medicinal Chemistry International Journal, 5(4), pp.107–112.
Boora, F., Chirisa, E. & Mukanganyama, S. (2014). Evaluation of nitrite radical scavenging properties of selected Zimbabwean plant extracts & their phytoconstituents. Journal of Food Processing, 2014.
Chan, E.W.C., Ng, V.P., Tan, V.V. & Low, Y.Y. (2011). Antioxidant & antibacterial properties of Alpinia galanga, Curcuma longa, & Etlingera elatior (Zingiberaceae). Pharmacognosy Journal, 3(22), pp.54–61.
Das, J., Ramani, R. & Suraju, M.O. (2016). Polyphenol compounds & PKC signaling. Biochimica et Biophysica Acta (BBA)-General Subjects, 1860(10), pp.2107–2121.
Devi, K.R., Singh, P.P., Medhapati Devi, M. & Sharma, G.J. (2018). Evaluation of Antioxidant Activities of Alpinia galanga (L.) Willd. Biosciences Biotechnology Research Asia, 15(4), pp.899–908.
Ekundayo, F.O., Adeboye, C.A. & Ekundayo, E.A. (2011). Antimicrobial activities & phytochemical screening of pignut (Jatrophas curcas Linn.) on some pathogenic bacteria. Journal of Medicinal Plants Research, 5(7), pp.1261–1264.
Ghosh, S. & Rangan, L. (2013). Alpinia: the gold mine of future therapeutics. 3 Biotech, 3(3), pp.173–185.
Ginting, C.N., Lister, I.N.E., Girsang, E., Riastawati, D., Kusuma, H.S.W. & Widowati, W. (2020). Antioxidant activities of Ficus elastica leaves ethanol extract & its compounds. Molecular & Cellular Biomedical Sciences, 4(1), pp.27–33.
Hajhashemi, V., Vaseghi, G., Pourfarzam, M. & Abdollahi, A. (2010). Are antioxidants helpful for disease prevention?. Research in Pharmaceutical Sciences, 5(1), pp.1–8.
Hermund, D.B. (2018). Antioxidant properties of seaweed-derived substances. In: Bioactive seaweeds for food applications. Elsevier.pp.201–221.
Lobo, V., Patil, A., Phatak, A. & Ch&ra, N. (2010). Free radicals, antioxidants & functional foods: Impact on human health. Pharmacognosy Reviews, 4(8), pp.118–126.
Lourenço, S.C., Moldão-Martins, M. & Alves, V.D. (2019). Antioxidants of natural plant origins: From sources to food industry applications. Molecules, 24(22), p.4132.
Melanathuru, V., Rengarajan, S. & Thangavel, N. (2017). Comparative study of antioxidant & anticancer activity of Alpinia calcarata & Alpinia galanga. International Journal of Pharmacy & Pharmaceutical Sciences, 9(12), pp.186–193.
Panche, A.N., Diwan, A.D. & Ch&ra, S.R. (2016). Flavonoids: an overview. Journal of nutritional science, 5.
Phaniendra, A., Jestadi, D.B. & Periyasamy, L. (2015). Free radicals: properties, sources, targets, & their implication in various diseases. Indian journal of clinical biochemistry : IJCB, [online] 30(1), pp.11–26.
Pontis, J.A., Costa, L.A.M.A. da, Silva, S.J.R. da & Flach, A. (2014). Color, phenolic & flavonoid content, & antioxidant activity of honey from Roraima, Brazil. Food Science & Technology, 34(1), pp.69–73.
Prahastuti, S., Hidayat, M., Hasiana, S.T., Widowati, W., Widodo, W.S., H&ayani, R.A.S., Rizal, R. & Kusuma, H.S.W. (2020). The ethanol extract of the bastard cedar (Guazuma ulmifolia L.) as antioxidants. Pharmaciana, 10(1), pp.77–88.
Ratnavathi, C. V & Komala, V. V. (2016). Sorghum grain quality. In: Sorghum biochemistry. Elsevier.pp.1–61.
Rusmana, D., Wahyudianingsih, R., Elisabeth, M., Balqis, B., Maesaroh, M. & Widowati, W. (2017). Antioxidant activity of Phyllanthus niruri extract, rutin & quercetin. The Indonesian Biomedical Journal, 9(2), pp.84–90.
Shalaby, E.A. & Shanab, S.M.M. (2013). Comparison of DPPH & ABTS assays for determining antioxidant potential of water & methanol extracts of Spirulina platensis.
Spiegel, M., Kapusta, K., Kołodziejczyk, W., Saloni, J., Żbikowska, B., Hill, G.A. & Sroka, Z. (2020). Antioxidant Activity of Selected Phenolic Acids–Ferric Reducing Antioxidant Power Assay & QSAR Analysis of the Structural Features. Molecules, 25(13), p.3088.
Srividya, A.R. & Dhanabal, S.P. (2011). Antioxidant & antidiabetic activity of Alpinia galanga. International journal of Pharmacognosy & phytochemical research, 3(01), pp.6–12.
Stevenie, S., Girsang, E., Nasution, A.N. & Lister, I.N.E. (2019). Comparison Activities of Peel & Extract of Lime (Citrus amblycarpa) as Antioxidant & Antielastase. American Scientific Research Journal for Engineering, Technology, & Sciences (ASRJETS), 57(1), pp.77–84.
Subramanian, P. & Nishan, M. (2015). Biological Activities of Greater galangal, Alpinia galanga—A Review. Res Rev J Bot Sci, pp.15–19.
Tungmunnithum, D., Tanaka, N., Uehara, A. & Iwashina, T. (2020). Flavonoids Profile, Taxonomic Data, History of Cosmetic Uses, Anti-Oxidant & Anti-Aging Potential of Alpinia galanga (L.) Willd. Cosmetics, 7(4), p.89.
Turati, F., Trichopoulos, D., Polesel, J., Bravi, F., Rossi, M., Talamini, R., Franceschi, S., Montella, M., Trichopoulou, A. & La Vecchia, C. (2014). Mediterranean diet & hepatocellular carcinoma. Journal of hepatology, 60(3), pp.606–611.
Utami, S., Sachrowardi, Q.R., Damayanti, N.A., Wardhana, A., Syarif, I., Nafik, S., Arrahman, B.C., Kusuma, H.S.W. & Widowati, W. (2018). Antioxidants, anticollagenase & antielastase potentials of ethanolic extract of ripe sesoot (Garcinia picrorrhiza Miq.) fruit as antiaging. Journal of Herbmed Pharmacology, 7(2), pp.88–93.
Valko, M., Morris, H. & Cronin, M.T.D. (2005). Metals, toxicity & oxidative stress. Current medicinal chemistry, 12(10), pp.1161–1208.
Wang, W. & Kannan, K. (2019). Quantitative identification of & exposure to synthetic phenolic antioxidants, including butylated hydroxytoluene, in urine. Environment international, 128, pp.24–29.
Widowati, W. (2011). Phytochemical assay & antioxidant potency of sappan wood ethanolic extract (Caesalpinia sappan L.). JKM, 11(1), pp.23–31.
Widowati, W., Wargasetia, T.L., Afifah, E., Mozef, T., Kusuma, H.S.W., Nufus, H., Arumwardana, S., Amalia, A. & Rizal, R. (2018). AJAB. Asian J Agri & Biol, 6(2), pp.149–161.
DOI: https://doi.org/10.22146/mot.72450
Article Metrics
Abstract views : 3161
| 
views : 1946
Refbacks
- There are currently no refbacks.
Copyright (c) 2022 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada