Subcrhonic Toxicity of Curcuma longa (Tumeric) Rhizoma Extract on Rats

https://doi.org/10.22146/mot.72259

Yani Mulyani(1*), Patonah Hasimun(2), Siti Nurjanah(3)

(1) Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Bhakti Kencana University, Bandung, West Java
(2) Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Bhakti Kencana University, Bandung, West Java
(3) Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Bhakti Kencana University, Bandung, West Java
(*) Corresponding Author

Abstract


Toxicity is a condition that indicates a harmful effect contained in a substance such as turmeric, which is an effective traditional medicinal plant used for antihypertensive treatment. Therefore, this study aims to determine the effect of repeated dosing of turmeric (Curcuma longa L.) rhizome extract. This subchronic toxicity study was divided into 4 groups, namely 1 normal treated with 0.5% Na-CMC, and 3 treatments with turmeric extract at doses of 50, 100, and 200 mg/kg BW for 28 days with each group consisting of 5 males and 5 female Wistar rats. The results showed that the turmeric extract at doses of 50, 100, and 200 mg/kg BW did not cause toxicity to liver and kidney biochemistry nor contain any toxic substances that might cause anemia or other abnormalities. Furthermore, histopathological examination showed that the tissues were normal. This indicates that the turmeric rhizome extract at all dose variations indicate non-toxic when used in traditional medicine.

Keywords


Biochemical; Curcuma longa; Hematology; Histopathology; Toxicity

Full Text:

PDF


References

Anugerah, A., Pratiwi, W. R., & Wahyuningsih, M. S. H. (2018). Pengaruh Kombinasi Ekstrak Tithonia diversifolia (Hemsley) A.Gray dan Curcuma domestica Val. pada Fungsi Hati dan Ginjal Tikus Model Kanker. Majalah Farmaseutik, 14(1), 1. https://doi.org/10.22146/farmaseutik.v14i1.41923

Asfour, V., Polson, A., Varma, R., & Menon, P. (2015). Clinical Obstetrics, Gynecology, and Reproductive Medicine Evaluating ovarian preservation after ovarian torsion using the ovarian preservation score and tissue necrosis score. January. https://doi.org/10.15761/COGRM.1000110

Balaji, S., & Chempakam, B. (2010). Toxicity prediction of compounds from turmeric (Curcuma longa L). Food and Chemical Toxicology, 48(10), 2951–2959. https://doi.org/10.1016/j.fct.2010.07.032

Chang, D. (2015). Cardiac allograft immune activation : current perspectives. 13–22.

Cheville, N. F. (1999). Introduction to Veterinary Pathology, Iowa State. University Press. PP.

Corwin, E. J., & Patofisiologi, B. S. (2001). Edisi 1. Jakarta: EGC.

Devi, F. L. (2015). Kadar Kreatinin, Asam Urat, dan Struktur Histologis Ren Tikus Putih (Rattus norvegicus Berkenhout, 1769) Dengan Induksi Jelantah dan Perlakuan Jus Sargassum spp. Universitas Gadjah Mada.

Elidiya, A., Ayu, P. R., Graharti, R., Kedokteran, F., & Lampung, U. (2019). Efek Curcumin Sebagai Pengobatan Penyakit Jantung Koroner Effect Of Curcumin As Coronary Heart Disease. 9, 244–248.

Hasimun, P., Mulyani, Y., Sulaeman, A., & Embas Sara, D. A. (2019). Prevention of Hypertension and Arterial Stiffness by Combination of Centella asiatica and Curcuma longa in Rats. Asian Journal of Biological Sciences, 12(2), 173–179. https://doi.org/10.3923/ajbs.2019.173.179

Higdon, J., Drake, V. J., Delage, B., & Howells, L. (2005). Curcumin. Linus Pauling Institute, Updated, 11(07).

Júnior, S. R., Diogo, A., Ii, F., Machado, T., Iii, D. A., Bortoletto, T., Iv, R., & Borges, L. B. (2014). Testicular histology after intestinal pedicle flap (cecum) apposition in rats Testicular histology after intestinal pedicle flap (cecum) apposition in rats 1 Histologia testicular depois da aposição de um retalho intestinal (ceco) em ratos. July. https://doi.org/10.1590/S0102-86502010000300005

Kim, Y., You, Y., Yoon, H. G., Lee, Y. H., Kim, K., Lee, J., Kim, M. S., Kim, J. C., & Jun, W. (2014). Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats. Food Chemistry, 151, 148–153. https://doi.org/10.1016/j.foodchem.2013.11.058

Kresnadipayana, D., Subianto, R. H., Faradilla, R., Studi, P., Kesehatan, D. A., Ilmu, F., Budi, U. S., Studi, P., Kesehatan, D. A., Ilmu, F., & Budi, U. S. (2019). Efek Subkronik Pemberian Ekstrak Etanol Kunyit ( Curcuma domestica Val ) Terhadap Hati Tikus Galur Wistar dengan Pemeriksaan SGOT dan SGPT Pendahuluan digunakan berupa rimpangnya untuk uji toksisitas adalah hati . Hati merupakan Glutamic Oxalacetic Transa. 77–85.

Longo, D. L., Fauci, A. S., Kasper, D. L., Hauser, S. L., Jameson, J. L., & Loscalzo, J. (2012). Harrison’s principles of internal medicine (Vol. 2012). Mcgraw-hill New York.

Matheos, C. (2014). Gambaran Histologik Jaringan Limpa Tikus Putih (Rattus norvegicus) yang Diinfeksi Eschericia Coli Dan Diberi Madu. Jurnal E-Biomedik, 1(2). https://doi.org/10.35790/ebm.1.2.2013.3251

Meyer, D. J., & Harvey, J. W. (2004). Veterinary Laboratory Medicine: Interpretation and Diagnosis, Saunders. St. Louis.

Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., & Howard, V. J. (2015). Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation, 131(4), e29–e322.

Mulyani Yani, Sukmawati Ika K, P. T. S. (2017). International Journal for Pharmaceutical Research Scholars (IJPRS) Effect from Repeated Dose of Ethanol Extract of Singawalang Leaves (Petiveria. International Journal for Pharmaceutical Research Scholars, 6(1–4), 20–24.

Olagunju, J. A., Adeneye, A. A., Fagbohunka, B. S., Bisuga, N. A., Ketiku, A. O., Benebo, A. S., Olufowobi, O. M., Adeoye, A. G., Alimi, M. A., & Adeleke, A. G. (2009). Nephroprotective activities of the aqueous seed extract of Carica papaya Linn. In carbon tetrachloride induced renal injured wistar rats: A dose- and time-dependent study. Biology and Medicine, 1(1), 11–19. https://doi.org/10.4172/0974-8369.1000002

Porwal, M., Khan, N. A., & Maheshwari, K. K. (2017). Evaluation of Acute and Subacute Oral Toxicity Induced by Ethanolic Extract of Marsdenia tenacissima Leaves in Experimental Rats. https://doi.org/10.3390/scipharm85030029

Salama, A., & EL BAHR, S. (2007). Effect of curcumin on cadmium-induced oxidative testicular damage in rats.

Saragih, S. P., Syawal, H., & Rauwaty, M. (2015). Total of Erythrocytes, Haematocrit, and Haemoglobin Changes of Pangasius hypophthalmus That Were Immersed In Curcumin Extract and That Were In Infected BY Aeromonas hydrophila. 1–14.

Sardjiman, S. (2000). Synthesis of some new series of curcumin analogues, antioxidative, antiinflammatory, antibacterial activities and qualitative-structure activity relationships [Thesis]. Yogyakarta: Universitas Gadjah Mada.

Sharma, V., Sharma, C., Paliwal, R., Pracheta, S. S., & Sharma, S. (2011). Ameliorative effects of Curcuma longa and curcumin on aflatoxin B1 induced serological and biochemical changes in kidney of male mice. Asian Journal of Biochemical and Pharmaceutical Research, 1(2), 338–351.

Sobolewski, C., Cerella, C., Dicato, M., Ghibelli, L., & Diederich, M. (2010). The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. International Journal of Cell Biology, 2010.

Venkatesan, N., Punithavathi, D., & Babu, M. (2007). Protection from acute and chronic lung diseases by curcumin. In The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease (pp. 379–405). Springer.

WHO. (2018). monitoring health for the SDGs, sustainable development goals. In World Health Organization 2018.

Winarsih, W., Wientarsih, I., Sulistyawati, N. P., & Wahyudina, I. (2012). Uji Toksisitas Akut Ekstrak Rimpang Kunyit pada Mencit : Kajian Histopatologis Lambung, Hati dan Ginjal. Jurnal Veteriner, Vol. 13(4), 402–409.



DOI: https://doi.org/10.22146/mot.72259

Article Metrics

Abstract views : 1598 | views : 1886

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2022 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada