Effects of Polyherbal Tablet for Hypertensive Patients

https://doi.org/10.22146/mot.62363

Woro Rukmi Pratiwi(1*), Eti Nurwening Sholikhah(2), Dwi Aris Agung Nugrahaningsih(3), Mia Munawaroh Yuniyanti(4), Mustofa Mustofa(5), Setyo Purwono(6)

(1) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(2) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(3) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(4) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(5) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(6) Departement of Pharmacology and Therapy, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Hypertension is a degenerative disease whose prevalence is high and continues to increase over time. Polyherbal tablet have long been used by Indonesian people for hypertension drugs containing garlic (Alium sativum), jelawe (Belericae fructus), temu ireng rhizomes (Curcumae aeruginosae) and kapulaga (Amomi fructus) extracts. This study aims to determine the effect of polyherbal tablet on hypertensive patients. The subjects of 29 hypertensive patients participated in a open-randomized-without comparison-study for 6 weeks. Subjects were divided into 3 groups, each subject received polyherbal tablet with a dose of 2x600 mg (group 1), 2x1200 mg (group 2) and 2x2400 mg (group 3). Blood pressure was monitored on D-0, D-3, D-5, D-7, W-2, W-3, W-4, W-5 and W-6. There was a significant decrease in systolic and diastolic blood pressure at the sixth week in all three treatment groups. The highest decrease in systolic blood pressure was in group 1 while diastolic blood pressure was in group 2 (-22.94 ± 5.871 and 13.13 ± 4.324 respectively). The lowest reduction in systolic and diastolic blood pressure occurred in the third group (-15.07 ± 3,519 and 8.98 ± 3,394 respectively). This study suggests that polyherbal tablet contains garlic (Alii sativi), jelawe (Belericae Fructus), temu ireng rhizome (Curcumae aeruginosae) and cardamom (Amomi Fructus) can reduce blood pressure in patients with hypertension. 


Keywords


Garlic; Belericae fructus; Curcumae aeruginosae; Amomi fructus; hypertension

Full Text:

PDF


References

Baradaran A, Nasri H, Kopaei MR., 2014, ‘Oxidative stress and hypertension: Possibility of hypertension therapy with antioxidants’, J res med sci. 19(4), 358-367.

Bouayed J and Bohn T., 2010, ‘Exogenous antioxidants-double edged swords in cellular redox state: health beneficial effects at physiologic doses versus deleterious effects at high doses’, Oxid Med Cell Longev. 3(4), 228-237.

Chavan LV, Anita P, Naresh P., 2010, ‘Antioxidant availability of beheda (terminalia bellerica (roxb.)) in relation to its medicinal uses’. PHCOG J. 2(10), 338-343.

Choudhury, D., Ghosal, M., Das, A.P., et al., 2013, ‘Development of single node cutting propagation techniques and evaluation of antioxidant activity of Curcuma aeruginosa, Roxburgh rihome’, IJPPS. 5(2), 227-234.

Guo DJ, Cheng HL, Chan SW, et al., 2008, ‘Antioxidative Activities and The Total Phenolic Contents of Tonic Chinese Medicinal Herbs’, Inflammopharmacology. 16, 201-207.

Guzik TJ and Touyz RM, 2017, ‘Oxidative Stress, Inflammation and Vascular Aging in Hypertension’, Hypertension. 1-9.

Hosseini A and Hosseinzadeh HA, 2015, ‘Review on the effects of Allium sativum (garlic) in metabolic syndrome’, J Endocrinol Invest.

James PA, Oparil S, Carter BL et al., 2014, ‘Evidence-Based Guideline for The Management of High Blood Pressure in Adults: Report From The Panel Members Appointed to The Eighth Joint National Committee (JNC 8)’, JAMA. 311(5), 507-520.

Khan AU and Gilani AH., 2012, ‘Pharmacodynamic evaluation of Terminalia bellerica for its antihypertensive effect’, Journal of Food and Drug Analysis. 16(3), 6-14.

Moon-ai W, Niyomploy P, Boonsombat R et al. 2012, ‘A superoxide dismutase purified from the rhizome of Curcuma aeruginosa roxb. as inhibitor of nitric oxide production in the macrophage-like RAW 264.7 cell line’, Appl Biochem Biotechnol. 166, 2138-2155.

Nampoothiri SV, Raj SSB, Prathapan A, et al., 2011, ‘In vitro antioxidant activities of the methanol extract and its different solvent fractions obtained from the fruit pericarp of Terminalia bellerica’. Natural Product Research. 25(3), 277-287.

Ngatidjan, Nugrahaningsih DAA., 2016, ‘Pengembangan Herbamon sebagai fitofarmaka untuk hipertensi melalui studi praklinik dan klinik (tahun 1)’, Laporan Penelitian PUPT-DRPM-Kemenristekdikti RI. Yogyakarta.

Nurcholis W, Khumaida N, Syukur M, et al., 2015,

‘Phytochemical screening, antioxidant and cytotoxic activities in extracts of different rhizome parts from curcuma aeruginosa roxb Int.’ J. Res. Ayurveda Pharm. 6, 634-637.

Rahimi K, Emdin CA, MacMahon S., 2015, ‘The Epidemiology of Blood Pressure and Its Worldwide Management’, Circulation Research. 925-936.

Ried K and Fakler P., 2014, ‘Potential of garlic (Allium sativum) in lowering high blood pressure: mechanisms of action and clinical relevance’, Integrated Blood Pressure Control. 7, 71–82.

Ried K, Travica N, Sali A., 2016, ‘The Effect of Aged Garlic Extract on Blood Pressure and Other Cardiovascular Risk Factors in Uncontrolled Hypertensives: The AGE at Heart Trial’ , Integrated Blood Pressure Control. 9, 9-21.

Ried K., 2014, ‘Garlic lower blood pressure in hypertensive individuals, regulates serum cholesterol, and stimulates immunity: an updated meta-analysis and review’, The journal of nutrition. 1-8.

Shouk R, Abdou A, Shetty K, et al., 2014, ‘Mechanisms underlying the antihypertensive effects of garlic bioactives’, Nutrition research. 34, 106-115.

Siti HN, Kamisah Y, Kamsiah J., 2015, ‘The Role of Oxidative Stress, Antioxidants and Vascular Inflammation in Cardiovascular Disease (A Review)’, Vascular Pharmacology, 71, 40-56.

Suru SM and Ugwu CE., 2015, ‘Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat’, J Basic Clin Physiol Pharmacol. 26(4), 347-354.

Wang HP, Yang J, Qin LQ, et al., 2015, ‘Effect of garlic on blood pressure: a meta-analysis’, The Journal of Clinical Hypertension. 17(3):223-231.

WHO., 2013, ‘A Global Brief on Hypertension: Silent Killer’, Global Public Health Crisis. Geneva.

Xiong XJ, Wang PQ, Li SJ et al., 2015, ‘Garlic for hypertension: a systematic review and meta-analysis of randomized controlled trials’, Phytomedicine. 22, 52-361.





DOI: https://doi.org/10.22146/mot.62363

Article Metrics

Abstract views : 2657 | views : 2651

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2020 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada