The Activity of Purple Sweet Potato Leaves (Ipomea batatas Ver.) Extract to Calcium Oxalate Concentration of Male Rat (Rattus novergicus)

https://doi.org/10.22146/mot.49423

Roihatul Mutiah(1), Avin Ainur Fitrianingsih(2), Yen Yen Ari Indrawijaya(3), Nabila Rahmadani(4*)

(1) Department of Pharmacy, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang
(2) Department of Pharmacy, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang
(3) Department of Pharmacy, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang
(4) Department of Pharmacy, Faculty of Medicine and Health Sciences, Maulana Malik Ibrahim State Islamic University, Malang
(*) Corresponding Author

Abstract


Purple sweet potato leaves (Ipomea batatas Ver.) has been proven to have anti-lithiasis effects in vitro in treating kidney stone disease. This is due to the high content of potassium in the leaves. The study aimed to analyze the effect of purple sweet potato leaf extract on kidney stone decay in male white rats induced by ethylene glycol 0.75% and ammonium chloride 2% for 10 days. In this study, 24 mice were divided into 6 groups: normal or without induction group, positive control, negative control, dose group 300 mg/200-gram body weight, 400 mg/200-gram body weight, and 500 mg/200-gram body weight. The parameters observed were calcium levels in the urine tested using Atomic Absorption Spectrophotometry, oxalate levels in urine tested using UV VIS Spectrophotometer. The results of this study indicate that purple sweet potato leaf extract at a dose of 500 mg/200-gram body weight can increase the levels of calcium and oxalate in the urine of rats compared with negative controls.


Keywords


Ipomea batatas Ver.; calcium; oxalate; ethylene glycol; ammonium chloride

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References

Afriyana, Djamilah dan MA. Hanny Ferry Fernanda. 2018. Analisis Kualitatif Dan Kuantitatif Cemaran Logam Berat Timbal (Pb) Dan Kadmium (Cd) Pada Produk Kosmetik Pensil Alis Menggunakanspektrofotometer Serapan Atom (Ssa). Journal of Research and Technology, Vol. 4 No. 1 Juni 2018.

Dharma S., Mimi A. dan Esa F.S., 2014. Pengaruh Ekstrak Etanol Daun Keji Beling (Strobilanthes Crispa (L) Blume) Terhadap Kelarutan Kalsium dan Oksalat Sebagai Komponen Batu Ginjal pada Urin Tikus Putih Jantan. Jurnal Scientia Vol 4 no 1 2014.

Fauzi, A. & Marco, M. A. P., 2016. Nefrolitiasis. Nefrolitiasis, 5(2).

Harbone, J.B. 1987. Metode Fitokimia Penuntun Cara Modern Menganalisis Tumbuhan. Padmawiyata K, Soediro I, Penerjemah. Terjemah dari: Phytochemical Methods. Bandung: ITB Press.

Konczak, I., and Zhang, W., 2004, “Anthocyanins–more than Nature’s Colours”, Journal of Biomedicine and Biotechnology, hal. 239–240.

Maharani, E. T., Mukaromah, A. H. & Susilo, J., 2012. Analisis Kalium Dan Prosentase Daya Larut Calsium Oksalat Oleh Kalium Dalam Air Teh Daun Sukun (Artocarpus Altilis). Seminar Hasil-Hasil Penelitian – LPPM UNIMUS.

Nisma F., 2011. Pengaruh Penambahan Ekstrak Etanol 70% Buah Anggur Biru (Vitis vinivera L.) Terhadap Kelarutan Kalsium Batu Ginjal. Jakarta: Farmasi FMIPA UHAMKA.

Sathish, R and Jayebalan, G. 2017. Study Of In Vitro Anti-Lithiatic Effect Of Ipomoea Batatas (L) Leaves And Tuberous Roots. Asian Journal of Pharmaceutical and Clinical Research Vol 11 Issues 2.

Sja’bani M. 2009. Batu Saluran Kemih dalam Buku Ajar Ilmu Penyakit Dalam Edisi 5. Jakarta: Interna Publising. Hal 1025 – 9

Sumarno & Mayangsari, A., 2016. Tanaman Obat Merupakan Komodity Indonesia Masa Depan. Jurnal Ilmiah Agribios, 14(2).

Vogel. 1985. Buku Teks Analisis Anorganik Kualitatif Makro dan Semimikro. Edisi kelima. Bagian I. PT Kalman Pustaka : Jakarta.

Wijaya, S dan Farida, L. D. (2005). Uji daya antikalkuli perasan buah ketimun (Cucumis sativus L.) terhadap tikus putih jantan dengan metode Kalkuli. Majalah Farmasi Indonesia, 16(3), 173 – 176, 2005





DOI: https://doi.org/10.22146/mot.49423

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