Penares sp sponge from Menjangan Island-water West Bali National Park: Isolation of Cytotoxic Compounds

https://doi.org/10.22146/mot.31547

Erna Prawita Setyowati(1*), Sudarsono Sudarsono(2), Retno Murwanti(3)

(1) Deprtment of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(2) Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(3) Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Sponges are multicellular animals which have cytotoxic compounds. In this study, isolation and cytotoxic activity of Penares sp sponge from Menjangan island-water West Bali National Park have been carried out. The results showed that chloroform extract and GF V Penares sp fraction were toxic according to Brine Shrimp Lethality Test method (each 85% and 63.3% mortality at 25μg/mL concentration). The isolation result of GF V fraction was obtained a compound (Spot 4) that is active as cytotoxic agent against T47D cells (IC50 of 12.7 ug/mL). Spot 4 is a terpenoid compound which has conjugated double bonds.

Keywords


Penares sp; spons; senyawa sitotoksik; sel T47D; sponge; cytotoxic agents; T47D cells;

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DOI: https://doi.org/10.22146/mot.31547

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